Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding

Interphase cells communicate directly with each other by exchanging ions and small molecules via gap junctions, which have important roles in controlling cell growth and differentiation. As cells round up during mitosis, the gap junctional communication between mitotic cells and adjacent interphase cells ceases.

Whether mitotic cells use alternative mechanisms for mediating direct cell-cell communication during mitosis is currently unknown. Here, we have studied the mechanisms involved in the remodeling of gap junctions during mitosis. We further demonstrate that mitotic cells are able to form actin-based plasma membrane bridges with adjacent cells during rounding.