Data · collection · 2016
New copper(II) complexes including pyridine-2,5-dicarboxylic acid: Synthesis, spectroscopic, thermal properties, crystal structure and how these complexes interact with purified PON 1 enzyme
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We report the synthesis of two square-pyramidal copper(II) complexes, [Cu(2,5-pydc)(2-aepy)(H 2 O)]·H 2 O, 1 , and [Cu(2,5-pydc)(2-ampy)(H 2 O)]·H 2 O, 2 (2-aepy = 2-(aminoethyl)pyridine, 2-ampy = 2-(aminomethyl)pyridine, 2,5-pydc = pyridine-2,5-dicarboxylic acid or isocinchomeronic acid).
Description
The synthesized complexes have been characterized by X-ray diffraction, FT-IR, elemental and thermal analysis techniques. The crystal structure of 1 was established by X-ray analysis.
Powder X-ray diffraction analysis showed that the complexes are pure. The inhibition of human serum paraoxonase 1 (PON 1, EC 3.1.8.1) enzyme with these complexes were investigated. We used diethyl 4-nitrophenyl phosphate as a substrate to measure the paraoxonase activity of PON 1 enzyme spectrophotometrically.
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Complexes 1 and 2 decreased the in vitro PON 1 activity with different inhibition mechanisms. Complexes 1 and 2 inhibited paraoxonase activity of this enzyme as competitively and uncompetitively, respectively.
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- Repository landing page figshare.com/collections/New_copper_II_complexes_including_pyridine_2_5_dic… ↗
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- DOI doi.org/10.6084/m9.figshare.c.3249328.v1 ↗
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Documentation and papers
- CC-BY creativecommons.org/licenses/by/3.0/us ↗
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- IsSupplementTo 10.1080/00958972.2016.1188295 doi.org/10.1080/00958972.2016.1188295 ↗
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- DataCite API api.datacite.org/dois/10.6084/m9.figshare.c.3249328.v1 ↗
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Topics
- Stated by source
- Biological sciences · Chemical sciences · Physical sciences
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Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.6084/m9.figshare.c.3249328.v1 | 12 d ago | JSON v1 |
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| concepts[field].fos:biological-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:chemical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:physical-sciences | source · DataCite | connector:datacite@1.0.0 | |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
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| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| updated_date | source · DataCite | connector:datacite@1.0.0 |