Enhancement of the solubility of BS Class II drugs with MOFs materials

<div>This thesis addresses the poor solubility of BCS Class II drugs (felodipine, ketoprofen, ibuprofen) by exploring metal-organic frameworks (MOFs) as drug carriers. </div><div>Chapter 1 introduces the problem and positions MOFs as a promising solution. </div><div>Chapter 2 details synthesis strategies and characterization methods. </div><div>Chapter 3 reports using HKUST-1 and its graphene oxide composite, showing improved loading and modified release (published work). </div><div>Chapter 4 introduces MIL-101(Cr) for its superior stability and biocompatibility, comparing adsorption and co-synthesis approaches.</div><div>Chapter 5 develops a rapid, room-temperature synthesis for Y-ZIF-8 with enhanced properties and drug loading capacity.</div>Chapter 6 summarizes findings and outlines future research directions.<br><br><i>Thesis is embargoed until 31 December 2027.</i>