Studies on a novel bioactive peptide, QUB-1264, extracted from the skin secretion of Odorrana schmackeri

Increasing numbers of antibiotics are not as effective as before, therefore, doctors and researchers are paying more attention to finding an alternative therapy to replace antibiotics. In this process, antimicrobial peptides which are small compounds with activity against a broad spectrum of microorganisms, have attracted attention.

On the other hand, the skin secretions of amphibians are a huge resource of antimicrobial peptides, generally expressing diverse bioactivity.<br><br>In this thesis, a novel bioactive peptide, QUB-1264, was identified from Odorrana schmackeri by molecular cloning, and it was successfully synthesised by solid phase peptide synthesis. RP-HPLC and MALDI-TOF MS were used to purify and confirm the structure of the target peptide.