Macrophage Polarization and Function at the Maternal-Fetal Interface in the Setting of Intrauterine Infection

Evidence suggests that up to 40% of preterm birth is caused by intrauterine infection (IUI) which triggers an inflammatory process in both the mother and fetus. Although much is known regarding the activity of neutrophils and other cells in IUI, less is known about macrophages.

Traditionally, the macrophage assumes M1 and M2 polarization which is either pro- or anti- inflammatory. Recent evidence has suggested that the macrophage in pregnancy does not fit into the aforementioned categories as neatly as assumed. Therefore, the macrophage deserves further investigation as a possible target for anti-inflammatories in the prevention of preterm birth.