Data · dataset · 2023
Paclitaxel, but Not Cisplatin, Affects Satellite Glial Cells in Dorsal Root Ganglia of Rats with Chemotherapy-Induced Peripheral Neurotoxicity
Listed in Bicocca Open Archive Research Data
Chemotherapy-induced peripheral neurotoxicity is one of the most common dose-limiting toxicities of several widely used anticancer drugs such as platinum derivatives (cisplatin) and taxanes (paclitaxel).
Description
Several molecular mechanisms related to the onset of neurotoxicity have already been proposed, most of them having the sensory neurons of the dorsal root ganglia (DRG) and the peripheral nerve fibers as principal targets.
In this study we explore chemotherapy-induced peripheral neurotoxicity beyond the neuronocentric view, investigating the changes induced by paclitaxel (PTX) and cisplatin (CDDP) on satellite glial cells (SGC) in the DRG and their crosstalk. Rats were chronically treated with PTX (10 mg/Kg, 1qwx4) or CDDP (2 mg/Kg 2qwx4) or respective vehicles. Morpho-functional analyses were performed to verify the features of drug-induced peripheral neurotoxicity.
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Qualitative and quantitative immunohistochemistry, 3D immunofluorescence, immunoblotting, and transmission electron microscopy analyses were also performed to detect alterations in SGCs and their interconnections. We demonstrated that PTX, but not CDDP, produces a strong activation of SGCs in the DRG, by altering their interconnections and their physical contact with sensory neurons. SGCs may act as principal actors in PTX-induced peripheral neurotoxicity, paving the way for the identification of new druggable targets for the treatment and prevention of chemotherapy-induced peripheral neurotoxicity.
Links
Where it is published
- DOI doi.org/10.17632/bf3xbd2mgw.1 ↗
DOI / persistent id · from board unimib it
Catalogue records · 1
- OAI-PMH record board.unimib.it/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Aboar… ↗
metadata API · from board unimib it
Topics
- From keywords
- Chemotherapy · Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Microscopy 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Bicocca Open Archive Research Data | oai:board.unimib.it/bf3xbd2mgw.1 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:field:321105 | mapping · board unimib it | vocabulary-mapper@1.0.0 | keywords['Chemotherapy'] |
| concepts[field].local:field:earth-environmental | mapping · board unimib it | connector:board_unimib_it@1.0.0 | |
| concepts[field].local:field:engineering | mapping · board unimib it | connector:board_unimib_it@1.0.0 | |
| concepts[field].local:field:humanities | mapping · board unimib it | connector:board_unimib_it@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · board unimib it | connector:board_unimib_it@1.0.0 | |
| concepts[field].local:field:social-science | mapping · board unimib it | connector:board_unimib_it@1.0.0 | |
| concepts[modality].local:modality:microscopy | enrichment · board unimib it | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · board unimib it | connector:board_unimib_it@1.0.0 | /metadata/dc/description |
| publication_date | source · board unimib it | connector:board_unimib_it@1.0.0 | |
| title | source · board unimib it | connector:board_unimib_it@1.0.0 | /metadata/dc/title |