Omics · study · 2026
RNA Sequencing of HMGB1-Driven Proliferation and Migration in Pulmonary Arterial Smooth Muscle Cells
Listed in NCBI GEO
Previous studies have demonstrated that HMGB1, functioning as a Damage-Associated Molecular Pattern (DAMP) molecule, is implicated in the pathological process of pulmonary arterial hypertension (PAH).
Description
The current study further investigated the underlying signaling pathways through which HMGB1 contributes to PAH. Transcriptomic analysis revealed HMGB1-associated differentially expressed genes (DEGs).
Gene Ontology (GO) enrichment analysis identified relevant transcriptomic pathways involved in HMGB1-mediated promotion of PAH.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301649 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301649 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1285917 ncbi.nlm.nih.gov/bioproject/PRJNA1285917 ↗
project · from NCBI GEO
- PubMed 42215667 pubmed.ncbi.nlm.nih.gov/42215667 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301649 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |