Omics · study · 2026
Changes in RNA expression underlying sustained antidepressant effects
Listed in NCBI GEO
We performed RNA-seq profiling of the medial prefrontal cortex (mPFC) in Wistar Kyoto (WKY) rats, an animal model of treatment-resistant depression.
Description
The WKY rats were treated for 7 days with either K-4, a novel positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), or racemic ketamine. After a 7-day drug withdrawal period, mPFC tissues were collected and subjected to RNA-seq analysis.
This study contributes to a understanding of the molecular mechanisms underlying the sustained antidepressant effects of ketamine.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298937 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298937 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1271972 ncbi.nlm.nih.gov/bioproject/PRJNA1271972 ↗
project · from NCBI GEO
- PubMed 41872515 pubmed.ncbi.nlm.nih.gov/41872515 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298937 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |