Identification of aging and senescence markers of male African turquoise killifish livers

However, many aspects remain unclear regarding the distinction between aging change and senescence at the body, organ and cell levels. In this study, we aimed to isolate molecular markers distinguishing aging change from senescence in the short-lived vertebrate African Turquoise killifish (N. furzeri).

First, the lifespan of N. furzeri was divided into growth (young), mature (adult), and senescent (old) stages. Changes between young and adult were defined as “aging change”, while changes between adult and old were defined as “senescence”. Metabolome and gene expression analyses of the liver identified several metabolites and genes as aging and senescence markers.