Omics · dataset · 2024
RNA-seq of bone marrow samples from acute myeloid leukemia patients and healthy individuals
Listed in DataCite
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults, characterized by the malignant transformation and uncontrolled proliferation of abnormal myeloid hematopoietic progenitor cells in the bone marrow.
Description
This study aims to analyze the pathogenesis and prognosis of AML by performing RNA-seq on bone marrow samples from both AML patients and healthy individuals. We collected a total of 20 bone marrow samples, consisting of 10 samples from AML patients and 10 from healthy controls, all of which were stored in liquid nitrogen.
The study received ethical approval (Ethical Approval Number: KY2024070), and all participants signed informed consent forms. This dataset includes the RNA-seq data from these samples. By analyzing the gene expression characteristics of myeloid progenitor cells, we attempt to construct a prognostic model to guide clinical treatment.
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These data not only aid in further exploring the molecular mechanisms of AML but also serve to identify new biomarkers and develop prognostic models, which are valuable for understanding the gene expression differences between AML and healthy bone marrow samples. The sharing of data from this study strictly adheres to ethical guidelines, with all sample collection and usage approved by the ethics committee and consented to by the participants.
Links
Where it is published
- Repository landing page datadryad.org/dataset/doi:10.5061/dryad.h9w0vt4t2 ↗
landing page · from DataCite
- DOI doi.org/10.5061/dryad.h9w0vt4t2 ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Zero v1.0 Universal creativecommons.org/publicdomain/zero/1.0/legalcode ↗
license · from DataCite
- IsCitedBy 10.3389/fimmu.2024.1494106 doi.org/10.3389/fimmu.2024.1494106 ↗
publication · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.5061/dryad.h9w0vt4t2 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.5061/dryad.h9w0vt4t2 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Basic medicine
- From keywords
- RNA sequencing
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.5061/dryad.h9w0vt4t2 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| byte_size | source · DataCite | connector:datacite@1.0.0 | |
| concepts[field].fos:basic-medicine | source · DataCite | connector:datacite@1.0.0 | |
| concepts[modality].local:modality:rna-seq | mapping · DataCite | vocabulary-mapper@1.0.0 | keywords['RNA-seq'] |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| version_label | source · DataCite | connector:datacite@1.0.0 |