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Data · dataset · 2026

Genomic Evidence for Imiquimod-Mediated Clearance of Mutated Skin in Xeroderma Pigmentosum

Listed in Teesside University Research Data Repository

In this study, we performed whole-exome sequencing of paired pre- and post-treatment biopsies from XP patients and demonstrated a consistent and substantial reduction in detectable somatic mutational burden following imiquimod therapy.

Description

We further characterized mutational signatures, showing persistence of oxidative damage–associated patterns in XP-V patients. Importantly, no tumors developed in treated areas during 24 months of follow-up.

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Earth & Environmental Science · Genetics · Life Sciences
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Sequencing 75%

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