Table 2_Association between vitamin D supplementation and mortality in elderly critically ill patients: a retrospective propensity score–matched cohort study.doc

However, evidence regarding the prognostic benefit of vitamin D supplementation in this population remains limited. This study aimed to investigate the association between vitamin D supplementation and 28-day mortality in elderly patients admitted to the intensive care unit (ICU).</p>Methods<p>This retrospective cohort study utilized data from the medical information mart for intensive care IV (MIMIC-IV) database, including patients aged ≥65 years.

Propensity score matching (PSM) balanced baseline characteristics between patients who received vitamin D within 48 h of ICU admission and those who did not. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs), and E-value analysis assessed unmeasured confounding.</p>Results<p>After PSM, 8,111 patients were included, with 1,338 (16.5%) deaths within 28 days. The 28-day mortality rate was significantly lower in the vitamin D supplementation group than in the non-supplemented group (14.5% vs. 17.0%, P = 0.017).