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Table · dataset · 2026

Table_1_Elevated serum uric acid is associated with cognitive improvement in older American adults: A large, population-based-analysis of the NHANES database.docx

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Background<p>The many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results.

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This study sought to investigate the relations between SUA and cognitive function in older adults.</p>Materials and methods<p>The sample was 2,767 American adults aged ≥60 years from the National Health and Nutrition Examination Survey 2011–2014. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease test, animal fluency test, digit symbol substitution test, and composite z-score.

Multivariate linear regression analyses were conducted to estimate the association between SUA and cognitive function.</p>Results<p>SUA level and cognitive function were significantly, positively correlated. Age significantly correlated with the association between SUA and cognitive function.</p>Conclusion<p>These findings support a connection between SUA and cognition, showing a positive link between SUA and cognitive scores among older American adults.

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We contend that a slight rise in uric acid within the normal range is advantageous for enhanced cognition. To confirm the precise dose-time-response relation, more tests will be needed.</p>

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Disease 75%
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