Data · dataset · 2023
HLA class I Sanger sequences data of Honduras HIV cohort
Listed in DataCite
HLA polymorphisms represent the strongest genetic modifier of HIV disease progression.
Description
Diverse HLA distribution can lead to distinct HIV control landscapes at the population level. We aimed to describe HLA allele and haplotype frequencies (linkage disequilibrium, LD), CCR5-Δ32 frequency and the impact of these variants on HIV disease outcome.
HLA class I (cI) loci were typed at 4-digit resolution, and CCR5 variants were determined in 402 HIV clade B-infected, ART-naïve individuals from Honduras. HLA LD were assessed using Fisher’s exact test. Using univariable and multivariable analyses we evaluated HLA associations with HIV pVL and CD4 counts.
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We did not find any effect on HIV control between CCR5 genotypes. Previously defined HLA associations were found: B*57:01/03, B*42:01, A*25:01 and C*12:03 (protective), and B*53:01 and A*68:01 (risk). Being consistent with our previous research in a Mesoamerican HIV cohort, Amerindian B*35:12 was associated to poor HIV control.
Other HLA-HIV associations not previously described were C*03:04 and B*08:01 that were associated with higher pVL. Overall, this first report highlights the immunogenetic uniqueness admixture of the Honduras population that express Amerindian, Caucasian and African HLA subtypes. These findings not only support this cohort as ideal for identifying HLA correlates of HIV control but also may improve future research regarding allotransplantation and disease association.
Links
Where it is published
- Repository landing page datadryad.org/dataset/doi:10.5061/dryad.x3ffbg7rc ↗
landing page · from DataCite
- DOI doi.org/10.5061/dryad.x3ffbg7rc ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Zero v1.0 Universal creativecommons.org/publicdomain/zero/1.0/legalcode ↗
license · from DataCite
- IsCitedBy 10.1128/spectrum.01613-23 doi.org/10.1128/spectrum.01613-23 ↗
publication · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.5061/dryad.x3ffbg7rc ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.5061/dryad.x3ffbg7rc ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Basic medicine
- Inferred from text
- Disease 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.5061/dryad.x3ffbg7rc | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| byte_size | source · DataCite | connector:datacite@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · DataCite | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].fos:basic-medicine | source · DataCite | connector:datacite@1.0.0 | |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| version_label | source · DataCite | connector:datacite@1.0.0 |