Data · dataset · 2026
Photocrosslinked sustained release biodegradable preformed implants for ocular drug delivery
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639061.v1
The thesis investigates the challenges associated with topical ocular formulations for prolonged treatment of various anterior ocular conditions due to limitations such as rapid elimination in the eye's biological environment.
Description
To overcome these challenges, researchers explore the use of photocrosslinked biodegradable implants composed of poly(ethylene glycol) diacrylate (PEGDA), poly(ethylene glycol) methacrylate (PEGMA), and poly(lactic-co-glycolic acid) (PLGA).
These hydrogel-based implants demonstrate versatility in delivering small molecule drugs, including timolol maleate, latanoprost, and dexamethasone, for conditions like glaucoma and posterior segment inflammation. The study comprehensively characterises these implants, assessing swelling properties, network parameters, mechanical strength, in vitro drug release profiles, biocompatibility, degradation patterns, and the impact of sterilisation.
Read the rest (1 more)
The findings suggest the potential of photocrosslinked biodegradable implants as a promising approach for sustained and tailored drug delivery to the eye over extended periods.<br><br><i>Thesis is embargoed until 31 July 2029</i>.<br><br>
Links
Where it is published
- DOI doi.org/10.17034/32639061.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639061 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639061 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639061 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |