Elucidating novel properties of adhesion motif functionalised peptide hydrogels with relevance for tissue engineering

Despite the knowledge that peptides can possess inherent antimicrobial properties, there has been little research to explore the antimicrobial properties of peptide hydrogels, specifically those functionalised with adhesion motifs. In this study, it was shown that the peptigels functionalised with the adhesion motifs RGD and GFOGER promoted an antimicrobial capacity, although dependent on the microorganism tested.<br><br>To create hydrogel scaffolds which are suitable for regeneration of the dentine-pulp complex, it is important that the matrix can support soft tissue regeneration, while not hindering an osteogenic response.

This work aimed to investigate the <i>in vitro</i> and <i>in vivo</i> osteogenic effects of the functionalised peptigels, where the hydrogels did not have a detrimental effect on osteogenesis. In conclusion, the functionalised peptide hydrogels may have potential for future use as regenerative endodontic therapies due to their biocompatibility with dental pulp cells, antimicrobial activity against oral pathogens and their non-detrimental effect on osteogenesis.<br><br><i>Thesis is embargoed until 31 December 2030</i>.