Elucidation and Control of the Reaction Network for Efficient Synthesis of Di-tert-amyl Peroxide in Microreactor

However, its traditional batch synthesis suffers from multiple side reactions with unclear mechanisms, poor interphase mass transfer, and intense heat release, ultimately leading to a low product quality. To address these challenges, a novel synthesis strategy coupled with mechanistic investigation is required to guide the DTAP production.

In this work, microreactor technology was employed to elucidate and control the reaction network for the efficient synthesis of DTAP. The complex reaction network of peroxidation was systematically deciphered, leading to the identification of three major classes of impurities, including 2-methyl-2-butene (MB), <i>tert</i>-amyl ethyl ether (TAEE), and the previously unreported compound 2,2-bis(<i>tert</i>-amyloxy)propane (BTAOP).