Excel · study · 2026
Transcriptome-wide m6A methylation profiling of penile tissues in a rat model of hypospadias
Listed in NCBI GEO
RNA modifications are an important component of epigenetic regulation and play essential roles in embryonic development.
Description
Among these modifications, N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNA, regulates diverse physiological and pathological processes. Increasing evidence suggests that dysregulated m6A methylation contributes to congenital malformations and reproductive system disorders.
In this study, methylated RNA immunoprecipitation sequencing (MeRIP-seq) was performed on penile tissues collected from normal rats and a rat model of hypospadias to characterize the transcriptome-wide m6A methylation landscape associated with hypospadias. These data provide a resource for investigating the potential role of m6A RNA methylation in the molecular mechanisms underlying hypospadias.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337280 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337280 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1484624 ncbi.nlm.nih.gov/bioproject/PRJNA1484624 ↗
project · from NCBI GEO
Topics
- Stated by source
- Other · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337280 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |