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Data · dataset · 2014

Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer

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The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers.

Description

We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523–524AC/del were associated with resistance to gastric cancer.

In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.

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Health sciences · Mathematics
Provenance · 1 source records, 15 field assertions
SourceKeyLast seenRaw
DataCite10.6084/m9.figshare.156872012 d agoJSON v1
FieldAssertionExtractorEvidence
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concepts[disease].local:disease:cancermapping · DataCitevocabulary-mapper@1.0.0keywords['Cancer']
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concepts[field].local:field:chemistrymapping · DataCitevocabulary-mapper@1.0.0keywords['Chemistry']
concepts[field].local:field:life-sciencesmapping · DataCitevocabulary-mapper@1.0.0keywords['Biological Sciences']
concepts[field].local:field:mathematics-statisticsmapping · DataCitevocabulary-mapper@1.0.0keywords['Mathematics']
concepts[field].local:field:medicine-healthmapping · DataCitevocabulary-mapper@1.0.0keywords['Medicine']
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