Effect of advanced glycation end products on endometrial receptivity in patients with polycystic ovary syndrome

Elevated levels of advanced glycation end products (AGEs) have been observed in women with PCOS, which are produced endogenously or absorbed from modern hot-processed diets, and data from in vitro experiments, animal models, and human studies suggest that AGEs may be involved in the pathogenesis of PCOS and its metabolic and reproductive consequences.

The purpose of this study was to investigate the accumulation of AGEs in in women and animal model with PCOS, and its effect on endometrial receptivity, and to explore the possible potential of AGEs receptor antagonist, N-Benzyl-N-cyclohexyl-4-chlorobenzamide (FPS-ZM1), in improving endometrial receptivity. In this study, Dehydroepiandrosterone (DHEA) was used to establish a PCOS rat model to explore the mechanism of AGEs affecting endometrial receptibility, and to explore the effectiveness of FPS-ZM1, in improving endometrial receptibility in PCOS rats.