Data · dataset · 2026
<p>Transcriptomic divergence of medulla neuropil glia along development.</p>
Listed in ZivaHub
<p><b>(A)</b> UMAP of medulla neuropil glia (mng) cells showing the divergence of astrocyte-like (ALG) and ensheathing (EG) glial cell types.
Description
The terminal fates identified in the adult dataset are circled. <b>(B)</b> UMAP showing cells colored by their developmental stages of origin. <b>(C)</b> UMAP-based subsetting of cells at the fork (colored red) between ALG and EG adult fates. Inset displays the proportion of red cells that belong to each developmental stage.
Note that the most represented stage at the trajectory fork is P30. <b>(D)</b> UMAP showing pseudotime alignment of mng glial cells. This pseudotime embedding is used for analyzing gene expression dynamics in <b>(E)</b>. <b>(E)</b> Heatmap of dynamically regulated TFs along pseudotime highlighting putative TFs associated with mng divergence (dashed box) and canonical Notch effector genes (blue arrowheads). <b>(F, F’)</b> L3 brain showing the lamina (F) and medulla (F’) neuropil glia stained for Hey (magenta) and Repo (cyan) antibodies.
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Both lamina and medulla neuropil glia express Hey after specification (full arrowheads) and turn it off shortly after (empty arrowheads). eg = epithelial glia, mg = marginal glia and mng = medulla neuropil glia. The code used to generate the graphs can be found at <a href="zenodo.org/records/21890456" target="_blank">zenodo.org/records/21890456</a>.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pbio.3004015.g005 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Cancer · Earth & Environmental Science · Genetics · Life Sciences · Medicine & Health · Plant biology
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34017688 | 10 d ago | JSON v1 |
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| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3108 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Plant Biology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |