Table · dataset · 2026
<p dir="ltr"><b>Antitumor activity of sea cucumber saponins via Wnt/β-catenin pathway inhibition in liver cancer cell</b></p>
Listed in HKU DataHub and figshare and Loughborough Research Repository and UP Research Data Repository — shown once because both records carry DOI 10.6084/m9.figshare.34011522.v1
<p dir="ltr">Hepatocellular carcinoma (HCC) is characterized by poor prognosis and limited therapeutic options, necessitating novel agents with selective efficacy and minimal toxicity.
Description
This study investigated the anticancer properties of saponin fraction (SPS) extracted from <i>Holothuria leucospilota</i> against HepG2 hepatocarcinoma cells. SPS were extracted and separated using chromatographic techniques.
Cytotoxicity was assessed via MTT assay in HepG2 and normal THLE-2 hepatocytes to determine the IC<sub>50</sub> and selectivity index (SI). Functional assays, including wound healing, transwell migration, colony formation, apoptosis (Annexin V/PI staining), and luciferase reporter assays, were conducted. Gene expression of Wnt/β-catenin pathway components was quantified using qPCR.
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SPS displayed potent cytotoxicity against HepG2 cells (IC<sub>50</sub> = 1.14 μg/mL) with high selectivity (SI = 2.04). SPS significantly inhibited migration, invasion, and colony formation while inducing apoptosis in a dose-dependent manner. Mechanistically, SPS reduced Wnt/β-catenin signaling activity, as evidenced by decreased SuperTOP/FOP ratios and downregulation of β-catenin, Cyclin D1, c-Myc, Wnt3a, LEF1, and MMP7 transcripts.
SPS exerts multifaceted antitumor effects in HCC, including induction of apoptosis, suppression of metastatic traits, and attenuation of Wnt/β-catenin signaling. Generally, SPS exhibited significant antiproliferative, anti-migratory, and pro-apoptotic effects in HepG2 cells, via modulation of the Wnt/β-catenin signaling pathway.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34011522.v1 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Cell development, proliferation and death · Cell development, proliferation and death · Cell development, proliferation and death · Cell development, proliferation and death · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Engineering · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Ocean & Atmospheric Science · Ocean & Atmospheric Science · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science · Social Science
- Inferred from text
- Cancer 75%
Provenance · 4 source records, 43 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/34011522 | 10 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34011522 | 10 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34011522 | 9 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/34011522 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:310102 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Cell development, proliferation and death'] |
| concepts[field].anzsrc:field:310102 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Cell development, proliferation and death'] |
| concepts[field].anzsrc:field:310102 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cell development, proliferation and death'] |
| concepts[field].anzsrc:field:310102 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cell development, proliferation and death'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |