Association of Sequence Similarity 13 Member A Gene Variants with the Risk of Chronic Obstructive Pulmonary Disease

Conducted as a hospital-based case-control investigation, this study sought to clarify whether selected single nucleotide polymorphisms in FAM13A influence the likelihood of developing COPD in older adults belonging to the Chinese Han population. The cohort comprised 541 participants, among whom 270 were diagnosed COPD patients and 271 served as healthy comparators.

DNA was isolated from peripheral blood leukocytes and subjected to microarray-based genotyping. Five SNPs---namely rs2602119, rs1801915, rs11944668, rs3756050, and rs2869950---were evaluated through multivariable logistic regression modeling, while potential epistatic interactions were probed via multifactor dimensionality reduction (MDR). Carriage of the rs2869950 C allele conferred greater odds of COPD occurrence.