Dataset for 'Refining cardiac pressure-volume metrics using real-time aortic flowmetry improves data accuracy and reduces animal burden in rat studies' [Lab Animal]

Thus, they can provide critical insights to basic, preclinical and clinical cardiology studies. However, the accuracy of PV indices is prone to dynamic perturbations in the calibration of the volume signal, particularly in small animals such as rodents.

Current calibration methods are not ideal to account for this. Here, we aimed to: 1) assess how well PV catheters track changes in stroke volume (SV) detected by gold-standard transit-time flowmetry, and 2) test a novel method for beat-by-beat calibration of PV-catheter volume data using real-time flowmetry (‘RTF’) data. We anesthetized and instrumented 10 male Wistar rats with a left-ventricular PV catheter and a perivascular flow probe around the ascending aorta, and manipulated cardiovascular function via several anesthetic and cardioautonomic blockade treatments.