Data · dataset · 2025
RNA sequencing data from: Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia
Listed in Researchdata.se
This dataset includes RNA sequencing (RNA-seq) data from the HNT-34 AML (acute myeloid leukemia) cell line after knockout of the SLAMF6 gene by CRISPR/Cas9 (SLAMF6-KO) or mock-knockout with a construct targeting the firefly luciferase gene (SLAMF6-WT).
Description
Libraries were produced using the Illumina stranded mRNA prep kit and sequenced on an Illumina Novaseq 6000 system (Illumina). The dataset is available as merged transcripts per million (TPM) data for all cases generated using Salmon (salmon.merged.gene_tpm.tsv.gz).
Raw sequencing reads (fastq) are available at the European Nucleotide Archive (ENA) under accession ID PRJEB90909: ebi.ac.uk/ena/browser/view/PRJEB90909. Published in: Sandén et al, Nature Cancer, 2025: nature.com/articles/s43018-025-01054-6
Links
Where it is published
- DOI doi.org/10.17044/scilifelab.28033754 ↗
DOI / persistent id · from researchdata se
Catalogue records · 1
- OAI-PMH record api.researchdata.se/oai-pmh?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3A… ↗
metadata API · from researchdata se
Topics
- From keywords
- Earth & Environmental Science · Medicine & Health
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| Researchdata.se | oai:researchdata.se:doi-10-17044-scilifelab-28033754/0 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · researchdata se | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · researchdata se | connector:researchdata_se@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata se | connector:researchdata_se@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · researchdata se | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · researchdata se | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · researchdata se | connector:researchdata_se@1.0.0 | /metadata/dc/description |
| license_text | source · researchdata se | connector:researchdata_se@1.0.0 | |
| publication_date | source · researchdata se | connector:researchdata_se@1.0.0 | |
| title | source · researchdata se | connector:researchdata_se@1.0.0 | /metadata/dc/title |