Data · dataset · 2026
Porcine astrovirus induces endoplasmic reticulum stress-mediated autophagic degradation of MAVS to inhibit type I interferon productionData
Listed in ScienceDB
Consequently, endoplasmic reticulum stress acts as the upstream trigger, the unfolded protein response serves as the immediate adaptive regulation, and autophagy emerges as the downstream rescue mechanism when the unfolded protein response is inadequate in alleviating the stress.
Description
Nevertheless, viruses have evolved sophisticated strategies to manipulate these cellular stress responses to their advantage. Specifically, certain viruses induce autophagy through ER stress to degrade key components of the host's antiviral innate immune system, thereby facilitating immune evasion(13, 14).
Currently, the mechanisms by which porcine astrovirus (PAstV) orchestrates ER stress and autophagy to enhance its replication remain to be elucidated.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.36413 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.36413 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |