16 datasets

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

Pancreatic cancer has been considered as the most lethal cancer type among adults for many decades. Especially with the failure to improve survival rates for the last 40 years, despite all the progress in targeting therapies. With the lack of therapeutic options, attention has been directed towards innovative platforms in a bid to overcome the resistant and aggressive nature of the disease.<br><br

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

This study aimed to evaluate the effectiveness of ALDH1a1 gene therapy in preventing diabetic retinopathy (DR), a neurovascular condition caused by diabetes and the toxic lipid aldehyde acrolein (ACR). The role of ALDH1a1 in detoxifying ACR was assessed both in vitro and in vivo. To model Müller cell dysfunction in DR, QMMuC-1 murine Müller cells were exposed to varying doses of ACR. The effects o

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

Lung cancer affects over 2 million people worldwide and became the major cause of death in cancer patients (18.4%) in 2018. The treatment of non-small cell lung cancer (NSCLC), accounting for 85% of total lung cancer, involves chemotherapy, radiotherapy, and surgery. However, such a therapeutic option for NSCLC demonstrate limited success in the treatment proved by the poor 5-year survival rate (~

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

<p dir="ltr">Protein engineering has evolved from modifying naturally occurring proteins toward modular, computational, and AI-assisted approaches for designing new molecular functions. Chimeric and fusion protein engineering has demonstrated that functional elements from different proteins can be reorganized into novel architectures, while advances in computational design, structure prediction, a

figshare2026 · Astronomical catalogue

<p>Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for regulating amyloid-β (Aβ) metabolism, tau pathology, neuroinflammation, gene

figshare2026 · Astronomical catalogue

<p>Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for regulating amyloid-β (Aβ) metabolism, tau pathology, neuroinflammation, gene

figshare2026 · Astronomical catalogue

<p>Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for regulating amyloid-β (Aβ) metabolism, tau pathology, neuroinflammation, gene

figshare2026 · Astronomical catalogue

<p>Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for regulating amyloid-β (Aβ) metabolism, tau pathology, neuroinflammation, gene

figshare2026 · Astronomical catalogue

<p>Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for regulating amyloid-β (Aβ) metabolism, tau pathology, neuroinflammation, gene

figshare2026 · Astronomical catalogue

<p>Alzheimer’s disease remains a major neurodegenerative disorder for which effective disease-modifying treatments are limited. Adeno-associated virus-mediated gene therapy provides a strategy for sustained modulation of disease-related pathways in the central nervous system. Recent studies have explored this approach for regulating amyloid-β (Aβ) metabolism, tau pathology, neuroinflammation, gene

figshare2026 · Astronomical catalogue

<p dir="ltr">This record contains the supplementary materials associated with the manuscript entitled “Comparative Efficacy of PLGA and Iron Oxide Nanocarriers for FOXM1 siRNA Delivery in Triple-Negative Breast Cancer Cells.” The files include supplementary figures, tables, and supporting Western blot membrane images related to the characterization and biological evaluation of PLGA and iron oxide

figshare2026 · Astronomical catalogue

<p dir="ltr">Yuzaki and colleagues identify biallelic CBLN1 variants as a cause of early-onset hereditary ataxia and show that loss of extracellular CBLN1 disrupts cerebellar synapses. Astrocyte-targeted AAV delivery restores synaptic CBLN1 and rescues circuit and motor dysfunction, establishing extracellular synaptic organizer replacement as a therapeutic strategy.</p>

IISH Dataverse2026 · dataset · unknown

Two recombinant bone morphogenetic proteins (BMP-2 and BMP-7) have received FDA approval for bone-related therapies. However, their clinical performance is limited by high costs, the need for supraphysiological doses, and adverse side effects. Here, we describe a chemically modified mRNA (cmRNA) encoding BMP-7 that promotes osteogenesis and functional ossification. The BMP-7 cmRNA is delivered usi

DataCite2024 · dataset

Tumor necrosis factor alpha-induced protein 9 (TNFAIP9) is a crucial effector molecule that protects cells from inflammatory and metabolic damage. This study focuses on investigating the role and regulatory mechanisms of TNFAIP9 in the progression of chronic kidney disease (CKD). By analyzing CKD-related datasets from the GEO database, we discovered that TNFAIP9 was upregulated in CKD patients and

Teesside University Research Data Repository2024 · dataset

CAR-T therapy drugs

CaltechDATA2021 · dataset

Engineered variants of recombinant adeno-associated viruses (rAAVs) are being developed rapidly to meet the need for gene-therapy delivery vehicles with particular cell-type and tissue tropisms. While high-throughput AAV engineering and selection methods have generated numerous variants, subsequent tropism and response characterization have remained low throughput and lack resolution across the ma