21 datasets

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

With a growing knowledge of the biology of cancer, a range of potential new drug targets have been identified, many of which are intracellular or difficult to target. Monoclonal antibodies and their derivatives have transformed the field of oncology, with monoclonal antibodies a current gold standard treatment both as single agents and in combination with other therapeutic approaches. However, the

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Gold nanoparticles (AuNPs) are effective radiosensitisers due to their high X-ray absorption and unique physicochemical properties. However, clinical translation is limited by the need for large treatment concentrations and passive accumulation. To overcome this, an antagonistic CXCR4-targeting ligand was conjugated to the AuNP surface, enabling target specificity. Additionally, the CXCL12 rich bo

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumour, classified as a grade IV astrocytoma, and is associated with extremely poor clinical outcomes. Standard-of-care treatment involves maximal surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ). Despite this multimodal therapeutic approach, patient prognosis is poor, with e

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

Delays in wound healing are a significant financial burden to the NHS with annual costs estimated to be £3.2 billion. Wound healing is regulated by microRNAs(miRs), which impact multiple aberrant genetic pathways. miR-31 and miR-132 canpromote re-epithelialisation, neoangiogenesis, and anti-inflammatory responses by targeting different molecular pathways. In this thesis, we have encapsulatedmiR-31

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Breast cancer (BC) is a highly heterogeneous disease at both the molecular and immune level. Recent evidence suggests that a key factor influencing response to treatment is the state of immune activation, with immune hot tumours (high levels of tumour infiltrating lymphocytes) associated with improved outcome.<br><br> Stimulator of Interferon Genes (STING), is an immune modulator implicated in sen

UCL Research Data Repository2026 · dataset · unknown

Despite major advancements in the treatment of many cancers, pancreatic cancer has one of the poorest survival rates of all, with a ten-year survival of less than 1%. One experimental clinical approach to treat pancreatic cancer had involved targeting an apoptosis pathway, the TNF-related apoptosisinducing ligand (TRAIL) receptor 2/ death receptor-5 (DR5) pathway using the monoclonal antibody cona

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Over the last decade, cancer immunotherapy in the form of immune checkpoint inhibitor (ICI) therapy has provided an effective treatment strategy for several cancer types that are unresponsive to other forms of treatment. However, a large subset of solid tumours, designated as being “cold” in nature, cannot respond to ICI therapy due to limited T-cell infiltration within the tumour following the su

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Pancreatic ductal adenocarcinoma (PDAC) remains a highly challenging disease with minimal improvements in clinical outcomes since the 1970s. The efficacy of currently available treatments is strongly limited by systemic toxicities, PDAC inherent chemoresistance, and the immunosuppressive nature of PDAC tumour microenvironment (TME). These challenges underscore the urgent need for novel therapeutic

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Targeting tumour microenvironment (TME) is an emerging strategy to fight cancer. In TME, cancer cells exhibit abnormal vasculature and altered metabolic states (anaerobic respiration instead of aerobic respiration) to cope with their high oxygen and nutrient demands. Remoulding TME via normalizing vasculature and preventing lactic acid transport contributes to the inhibition of tumour development.

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · Imaging · unknown

For those suffering from cancer nanoparticle-enhanced radiotherapy has shown great potential as a means to improve patient outcome. In order to maximise the benefit obtained from such treatment a full understanding of the uptake dynamics of nanoparticles is required. As such the aim of this body of work is to conceptualise and experimentally demonstrate novel approaches to probe the uptake of gold

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

In women, breast cancer (BC) is the most common cancer and despite improvements in long-term outcomes, recurrence is still significant. Unfortunately, metastatic disease is incurable with only 26% of BC patients reaching a 5-year survival rate.Bisphosphonates (BPs) are potent inhibitors of bone resorption and extensively used for the prevention and treatment of secondary bone cancer in BC patients

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Triple Negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer, accounting for approximately 15-20% of all cases yet contributing to nearly 40% of breast cancer-related deaths. These tumours are characterised by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 amplification, meaning they do not benefit from targeted endocrine or HER2-dir

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Leukaemia has the highest incidence and mortality among haematological malignancies and is the most common childhood cancer. Despite advancements, current therapies largely rely on non-targeted chemotherapy, associated with severe side effects and limited efficacy. Nanoparticles (NPs) have shown promise in the treatment of acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL), with t

figshare2026 · Astronomical catalogue

<p dir="ltr">Here, we designed optimal conditions for high drug loading efficiency of 2AT and ²²³Ra with mutually improving therapeutic mechanisms of chemotherapy and α-radionuclide therapy. Importantly, the incorporation of 2AT and radiolabeling with ²²³Ra resulted in a slower dissolution of the CaCO₃ microparticles compared with the unloaded carrier. The resultin

figshare2026 · Astronomical catalogue

<p dir="ltr">This record contains the supplementary materials associated with the manuscript entitled “Comparative Efficacy of PLGA and Iron Oxide Nanocarriers for FOXM1 siRNA Delivery in Triple-Negative Breast Cancer Cells.” The files include supplementary figures, tables, and supporting Western blot membrane images related to the characterization and biological evaluation of PLGA and iron oxide

Borealis2026 · dataset · unknown

Supplementary data for a manuscript

Teesside University Research Data Repository2025 · dataset

The obtained cDNA library was then sequenced on the Illumina platform. The raw data was filtered using Trimmomatic, resulting in clean data. Reads were aligned to the reference genome with HISAT2 (version: 2.2.1). For three biological replicates, DESeq2 (version: 1.34.0) was used to identify differentially expressed genes, while edgeR (version: 3.36.0, dispersion = 0.01) was applied for datasets w

Teesside University Research Data Repository2025 · dataset

This dataset presents a comprehensive physicochemical profile of Sargassum Muticum-mediated CaO nanoparticles. X-ray diffraction patterns contain information about structural characteristics. UV-visible spectroscopy data demonstrates optical absorption properties. Fourier-transform infrared spectra identify molecular vibrations and chemical bonds. Thermogravimetric analysis profiles show thermal b

Teesside University Research Data Repository2023 · dataset

Dataset relative to the work: Godel et al. 2023 Tumor-targeted perfluorinated micelles as efficient theranostic agents combining positron emission tomography and radiosensitization Contains raw and processed data for all results presented in the above article.

Teesside University Research Data Repository2023 · dataset

Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were optimized using the Box–Behnken design (BBD). The optimized Asp/TLs exhibited an average particle size of 114.05 ± 1.56 nm, PDI of 0.15 ± 0.015, zeta potential of −15.24 ± 0.65 mV, and entrapment efficiency (EE%) of 84.08 ± 2.75%.

ZivaHub + Deakin Research Online2019 · Crystal structure

Ovarian cancer is the second most common gynaecological malignancy. It usually occurs in women older than 50 years, and because 75% of cases are diagnosed at stage III or IV it is associated with poor diagnosis. Despite the chemosensitivity of intraperitoneal chemotherapy, the majority of patients is relapsed and eventually dies. In addition to the challenge of early detection, its treatment prese