Data · dataset · 2026
Development of a nanomedicine in an electrospun patch for wound healing
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32633064.v1
Delays in wound healing are a significant financial burden to the NHS with annual costs estimated to be £3.2 billion.
Description
Wound healing is regulated by microRNAs(miRs), which impact multiple aberrant genetic pathways. miR-31 and miR-132 canpromote re-epithelialisation, neoangiogenesis, and anti-inflammatory responses by targeting different molecular pathways. In this thesis, we have encapsulatedmiR-31 and miR-132 into nanoparticles (NP) by electrostatic interaction with RALA, a novel 30-mer amphipathic pH-responsive peptide that is designed to overcome biological barriers.
A wound dressing with potential for NP loadingand delivery has been fabricated using electrospinning. Polyvinyl alcohol was chosen as the carrier polymer owing to its ability to be electrospun, sodiumalginate was incorporated for its wound healing ability and ciprofloxacin wasadded as a wide-spectrum antibiotic. The NP cocktail has been proven to efficiently enter cells with no cytotoxicity, to upregulate miR levels, and to increase cell migration.
Read the rest (1 more)
Our NP-loaded electrospun nanofibre technology has demonstrated in vitro antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus, as well as biocompatibility and the promotion of keratinocyte migration in wound scratch assays. Treatment with the loaded nanofibres in a full thickness wound model in C57BL/6N mice resulted in an increase in wound healing rate, as well as a thicker epidermal layer and a heightened blood vessel count. <br><br><i>Thesis embargoed until 31 December 2027 </i>
Links
Where it is published
- DOI doi.org/10.17034/32633064.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Nanomedicine · Nanomedicine · Nanomedicine · Nanomedicine
Provenance · 4 source records, 21 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32633064 | 8 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32633064 | 8 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32633064 | 8 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32633064 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:320604 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['nanomedicine'] |
| concepts[field].anzsrc:field:320604 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['nanomedicine'] |
| concepts[field].anzsrc:field:320604 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['nanomedicine'] |
| concepts[field].anzsrc:field:320604 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['nanomedicine'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |