85 datasets

NCL Data2026 · dataset

<p>Functional Janus biomaterials, characterized by asymmetric architectures, have emerged as promising platforms for regenerative medicine because of their capacity to integrate distinct yet complementary functions within a single construct. By spatially compartmentalizing physicochemical, biological, and therapeutic functionalities, these systems can better address the heterogeneous and dynamic r

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

With a growing knowledge of the biology of cancer, a range of potential new drug targets have been identified, many of which are intracellular or difficult to target. Monoclonal antibodies and their derivatives have transformed the field of oncology, with monoclonal antibodies a current gold standard treatment both as single agents and in combination with other therapeutic approaches. However, the

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Gold nanoparticles (AuNPs) are effective radiosensitisers due to their high X-ray absorption and unique physicochemical properties. However, clinical translation is limited by the need for large treatment concentrations and passive accumulation. To overcome this, an antagonistic CXCR4-targeting ligand was conjugated to the AuNP surface, enabling target specificity. Additionally, the CXCL12 rich bo

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumour, classified as a grade IV astrocytoma, and is associated with extremely poor clinical outcomes. Standard-of-care treatment involves maximal surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ). Despite this multimodal therapeutic approach, patient prognosis is poor, with e

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

Delays in wound healing are a significant financial burden to the NHS with annual costs estimated to be £3.2 billion. Wound healing is regulated by microRNAs(miRs), which impact multiple aberrant genetic pathways. miR-31 and miR-132 canpromote re-epithelialisation, neoangiogenesis, and anti-inflammatory responses by targeting different molecular pathways. In this thesis, we have encapsulatedmiR-31

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Breast cancer (BC) is a highly heterogeneous disease at both the molecular and immune level. Recent evidence suggests that a key factor influencing response to treatment is the state of immune activation, with immune hot tumours (high levels of tumour infiltrating lymphocytes) associated with improved outcome.<br><br> Stimulator of Interferon Genes (STING), is an immune modulator implicated in sen

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

Pancreatic cancer has been considered as the most lethal cancer type among adults for many decades. Especially with the failure to improve survival rates for the last 40 years, despite all the progress in targeting therapies. With the lack of therapeutic options, attention has been directed towards innovative platforms in a bid to overcome the resistant and aggressive nature of the disease.<br><br

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

Induced pluripotent stem cell-derived endothelial cells (iPS-ECs) hold clear potential for therapeutic angiogenesis in ischaemic diseases, although many challenges remain such as enrichment and expansion of homogenous, mature, highly proliferative and functional ECs. It is well established that reactive oxygen species (ROS), which are centrally involved in ischaemic disease, are important regulato

UCL Research Data Repository2026 · dataset · unknown

Despite major advancements in the treatment of many cancers, pancreatic cancer has one of the poorest survival rates of all, with a ten-year survival of less than 1%. One experimental clinical approach to treat pancreatic cancer had involved targeting an apoptosis pathway, the TNF-related apoptosisinducing ligand (TRAIL) receptor 2/ death receptor-5 (DR5) pathway using the monoclonal antibody cona

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Over the last decade, cancer immunotherapy in the form of immune checkpoint inhibitor (ICI) therapy has provided an effective treatment strategy for several cancer types that are unresponsive to other forms of treatment. However, a large subset of solid tumours, designated as being “cold” in nature, cannot respond to ICI therapy due to limited T-cell infiltration within the tumour following the su

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Pancreatic ductal adenocarcinoma (PDAC) remains a highly challenging disease with minimal improvements in clinical outcomes since the 1970s. The efficacy of currently available treatments is strongly limited by systemic toxicities, PDAC inherent chemoresistance, and the immunosuppressive nature of PDAC tumour microenvironment (TME). These challenges underscore the urgent need for novel therapeutic

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Targeting tumour microenvironment (TME) is an emerging strategy to fight cancer. In TME, cancer cells exhibit abnormal vasculature and altered metabolic states (anaerobic respiration instead of aerobic respiration) to cope with their high oxygen and nutrient demands. Remoulding TME via normalizing vasculature and preventing lactic acid transport contributes to the inhibition of tumour development.

ZivaHub + Deakin Research Online + DMU Figshare2026 · Crystal structure

In the age of advanced polymer science and regenerative medicine, biomaterial platforms are being developed that combine therapeutic functionality and molecular precision, providing fresh hope for the treatment of complex diseases, such as cancer. Translating these adaptable chemistries into biomedical practice necessitates a nuanced comprehension of how subtle variations in network formation mech

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · Imaging · unknown

For those suffering from cancer nanoparticle-enhanced radiotherapy has shown great potential as a means to improve patient outcome. In order to maximise the benefit obtained from such treatment a full understanding of the uptake dynamics of nanoparticles is required. As such the aim of this body of work is to conceptualise and experimentally demonstrate novel approaches to probe the uptake of gold

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

In women, breast cancer (BC) is the most common cancer and despite improvements in long-term outcomes, recurrence is still significant. Unfortunately, metastatic disease is incurable with only 26% of BC patients reaching a 5-year survival rate.Bisphosphonates (BPs) are potent inhibitors of bone resorption and extensively used for the prevention and treatment of secondary bone cancer in BC patients

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

Diabetic endotheliopathy is the main cause for impaired angiogenesis and reduced neovascularization that lead to microvascular injury and vascular complications. The pathogenesis for vascular complications arising from diabetes is complex. Elucidation of key underlying mechanisms will help the development of novel therapies and the discovery of potential biomarkers. The ability to generate functio

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

This study aimed to evaluate the effectiveness of ALDH1a1 gene therapy in preventing diabetic retinopathy (DR), a neurovascular condition caused by diabetes and the toxic lipid aldehyde acrolein (ACR). The role of ALDH1a1 in detoxifying ACR was assessed both in vitro and in vivo. To model Müller cell dysfunction in DR, QMMuC-1 murine Müller cells were exposed to varying doses of ACR. The effects o

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Triple Negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer, accounting for approximately 15-20% of all cases yet contributing to nearly 40% of breast cancer-related deaths. These tumours are characterised by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 amplification, meaning they do not benefit from targeted endocrine or HER2-dir

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset

Lung cancer affects over 2 million people worldwide and became the major cause of death in cancer patients (18.4%) in 2018. The treatment of non-small cell lung cancer (NSCLC), accounting for 85% of total lung cancer, involves chemotherapy, radiotherapy, and surgery. However, such a therapeutic option for NSCLC demonstrate limited success in the treatment proved by the poor 5-year survival rate (~

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Leukaemia has the highest incidence and mortality among haematological malignancies and is the most common childhood cancer. Despite advancements, current therapies largely rely on non-targeted chemotherapy, associated with severe side effects and limited efficacy. Nanoparticles (NPs) have shown promise in the treatment of acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL), with t

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

<p dir="ltr">Protein engineering has evolved from modifying naturally occurring proteins toward modular, computational, and AI-assisted approaches for designing new molecular functions. Chimeric and fusion protein engineering has demonstrated that functional elements from different proteins can be reorganized into novel architectures, while advances in computational design, structure prediction, a

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · RNA sequencing · unknown

Diabetic retinopathy (DR) is the most frequently occurring microvascular complication of diabetes mellitus, where the later stages of the disease are often is chaemia driven which can result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, which is significantly impacted by the diabetic milieu. It has now been established that the endotheli

figshare + Loughborough Research Repository2026 · Astronomical catalogue

Aim<p>Three-dimensional (3D) bioprinting enables fabrication of bioink-based scaffolds that mimic native tissue architecture. This systematic review aims to evaluate the safety profile and healing times of 3D-bioprinted scaffolds clinically tested in human lower limb ulcers.</p>Methods<p>A systematic review was conducted in accordance with PRISMA guidelines. PubMed, Embase, Scopus, and Web of Scie

figshare + Loughborough Research Repository2026 · Astronomical catalogue

Aim<p>Three-dimensional (3D) bioprinting enables fabrication of bioink-based scaffolds that mimic native tissue architecture. This systematic review aims to evaluate the safety profile and healing times of 3D-bioprinted scaffolds clinically tested in human lower limb ulcers.</p>Methods<p>A systematic review was conducted in accordance with PRISMA guidelines. PubMed, Embase, Scopus, and Web of Scie

figshare + Loughborough Research Repository2026 · Astronomical catalogue

<p dir="ltr">This dataset is associated with the FSRI Study on the fire safety of E-mobility devices on passenger rail cars. More information can be found at <a href="https://fsri.org/research-update/report-examines-fire-safety-hazards-e-mobility-devices-passenger-railcars" target="_blank">FSRI.org</a>. The full project report can be found <a href="https://doi.org/10.60752/102376.32136697" target=