13,068 datasets

ETH Zürich Research Collection2027 · Image data

ETH Zürich Research Collection2026 · Image data

California Open Data2026 · Image data

The Interagency Ecological Program’s (IEP) Fall Midwater Trawl Survey (FMWT) is a long-term monitoring survey conducted by the California Department of Fish and Wildlife (CDFW) and has sampled annually since its inception in 1967, with the exceptions of 1974 and 1979, when sampling was not conducted. The FMWT was initiated to determine the relative abundance and distribution of age-0 Striped Bass

NCBI GEO2026 · Image data · 32 samples

The tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in diffuse large B-cell lymphoma (DLBCL), but HIV-associated DLBCL remains poorly understood. We performed spatial transcriptomics on pre-treatment DLBCL biopsies to characterize the TIME and tumor-intrinsic features across a spectrum of HIV-associated immune dysregulation. Our analysis reveal

NCBI GEO2026 · Image data · 2 samples

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a complex tumor microenvironment that may be altered by neoadjuvant chemotherapy. As part of an exploratory multi-omics study focused on lipid-associated macrophages (LAMs), we performed 10x Genomics Visium CytAssist spatial transcriptomic profiling of formalin-fixed, paraffin-embedded PDAC tumor specimens. This dataset includes spatial t

ETH Zürich Research Collection2026 · Image data

Functional assessment of microengineered cardiac and skeletal muscle tissues anchored to flexible posts is widely implemented in preclinical disease modeling and pharmacology. However, existing procedures for tissue stimulation, image acquisition, and analytical processing remain largely manual, tedious, and low-throughput. Here, we demonstrate that integrating mechanized gantry-based video acquis

NCBI GEO2026 · Image data · 11 samples

Background Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by loss-of-function mutations in COL7A1 encoding type VII collagen (C7). Patients with RDEB suffer since birth from skin and mucosal blistering and develop severe local and systemic complications resulting in poor prognosis. Mesenchymal stromal cells (MSCs) demonstrated potential to improve wound healing a

NCBI GEO2026 · Image data · 2 samples

Children experience an average of 14 infections and receive vaccines against roughly 15 distinct pathogens within their first three years of life. Despite the alarming global rise in maternal and childhood obesity, its impact on early-life adaptive immune responses to vaccination or infection remains largely undefined. Using a mouse model that mirrors the epidemiological link between maternal and

NCBI GEO2026 · Image data · 4 samples

Cryptorchidism is a common congenital disorder of the male reproductive system in dogs. We used the 10x Genomics Visium Spatial Gene Expression platform to profile four testicular tissue sections from two dogs with unilateral cryptorchidism: an abdominally retained testis and its contralateral descended testis, and an inguinally retained testis and its contralateral descended testis. The data reve

NCBI GEO2026 · Image data · 16 samples

Aging-related cognitive decline, including impairments in spatial orientation and memory, has been linked to dysfunction within the hippocampus and medial entorhinal cortex (MEC). However, the cellular and molecular alterations underlying MEC aging remain poorly understood. Here we show that old mice exhibit a reduced proportion of grid cells and decreased spatial stability. Transcriptomic profili

NCBI GEO2026 · Image data · 6 samples

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of hepatocellular carcinoma (HCC). How liver metabolic zonation dictates regional malignant transformation remains unclear. We identify SIRT2 as a zonated cholesterol sensor that initiates periportal metabolic reprogramming to drive MASLD-HCC. Lineage tracing establishes zone 1 hepatocytes as the exclusive tumor or

NCBI GEO2026 · Image data · 8 samples

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and structural remodelling across different anatomical structures of the lung, including airways, parenchyma, and pulmonary vessels. However, compartment specific changes in immune cells composition and their communications with underlying structural cells is under investigated. Our study sought to assess the spa

NCBI GEO2026 · Image data · 3 samples

Spatial transcriptomics was performed on skin samples from TyrCreER;MRGPRX4-ROSA26-stop-flox animals. Spatial analysis revealed mutiple, spatially defined melanoma states.

NCBI GEO2026 · Image data · 2 samples

Resistance to immune checkpoint blockade (ICB) remains a major barrier in non-small cell lung cancer (NSCLC), where defective antigen presentation, myeloid-cell dominance, and immune exclusion limit anti-tumor immunity. Here, we show that IL-12/FLT3L-armed dendritic-cell progenitors (DCPs) overcome these barriers by reprogramming the tumor microenvironment into an immune-responsive ecosystem domin

ETH Zürich Research Collection2026 · Image data

NCBI GEO2026 · Image data · 3 samples

Most methods to generate neocortical organoids from human pluripotent stem cells lack clear evidence for anterior and posterior polarization, which eventually parcellate into different areal identities with unique cytoarchitecture, cell composition, connectivity, and gene expression patterns in vivo. This study demonstrates the polarization of neocortical organoids. By adding rostral (FGF8) and ca

NCBI GEO2026 · Image data · 4 samples

Neutrophils have been implicated in mediating immune crosstalk between injured tissue and distal organs, either promoting local and distal inflammation or mediating tissue repair. Skin injury from ultraviolet (UV) light triggers neutrophil migration to the kidney, which may have implications for nephritis flares in systemic lupus erythematosus (SLE). Here, we demonstrate that after skin exposure t

ETH Zürich Research Collection2026 · Image data

Endothelial cells were among the first cells identified to have a surface glycocalyx, but its functions are still elusive. Within the glycocalyx are many glycoproteins whose O-glycosylation is partly regulated by Cosmc, an essential chaperone for functional activity of T-synthase that adds galactose to O-glycans initiating their elongation. Using mice with inducible deletion of either Cosmc (C1Gal

NCBI GEO2026 · Image data · 5 samples

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease in which severe disease is characterized by epithelialized dermal tunnels that are poorly responsive to medical therapy. We used spatial transcriptomics to show that severe HS tunnel epithelium have a conserved transcriptional program different from that of the overlying epidermis. Pathway and differential gene intersection analy

NCBI GEO2026 · Image data · 7 samples

Limb regeneration requires rebuilding the missing structures and integrating them with stump tissues. Osteoclast-mediated tissue resorption is essential for skeletal integration during regeneration. However, it is unknown if skeletal tissue composition impacts its resorption and, if so, how it is regulated. Here, we show that osteoclast-mediated skeletal resorption is activated in amputations dama

NCBI GEO2026 · Excel spreadsheet · 4 samples

Hibernation is an extreme physiological state in certain mammals that is characterized by a reversible reduction in metabolic and thermogenic demands. Although the preoptic area has been implicated in the regulation of hibernation, comprehensive molecular and spatial resources for this brain region in hibernating mammals remain limited. Here, we present an integrated transcriptomic resource of the

NCBI GEO2026 · Image data · 2 samples

Delayed and non-healing fractures, affecting 5–10% of cases, are associated with prolonged disability and diminished quality of life. Although acute inflammation is required to initiate repair, persistent mechanical instability can sustain maladaptive immune and fibrotic responses that impede regeneration. Existing animal models do not adequately recapitulate mechanical instability, the principal

NCBI GEO2026 · Image data · 2 samples

The Omicron sub-lineages of SARS-CoV-2 have caused a significant acute disease burden on human health and strained public health and healthcare services, while eliciting chronic disease outcomes as well. As such, the development of animal models that provoke acute and chronic disease phenotypes are essential for understanding disease mechanisms and for development of interventional countermeasures

NCBI GEO2026 · Image data · 4 samples

Spatial transcriptomic analysis of Mycoplasma hyopneumoniae infection in porcine lung tissue using 10x Genomics Visium platform. Forty-eight pigs (24 Chenghua and 24 Yorkshire) were divided into infection and control groups. Lung tissues were collected at days 28 post-infection. Twelve samples underwent spatial transcriptomic sequencing: CHI (n=4), YYI (n=4), CHC (n=2), and YYC (n=2).

NCBI GEO2026 · Image data · 2 samples

This study characterized spatial gene-expression patterns in calcified human coronary artery tissue using the 10x Genomics Visium CytAssist workflow.