159 datasets

figshare + Loughborough Research Repository2026 · Astronomical catalogue

…Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics.… …Single-cell analysis showed that these genes were predominantly expressed in fibroblasts and associated with fibroblast-state changes and ECM remodeling.…

figshare + Loughborough Research Repository2026 · Astronomical catalogue

…Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics.… …Single-cell analysis showed that these genes were predominantly expressed in fibroblasts and associated with fibroblast-state changes and ECM remodeling.…

figshare + Loughborough Research Repository2026 · Astronomical catalogue

…Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics.… …Single-cell analysis showed that these genes were predominantly expressed in fibroblasts and associated with fibroblast-state changes and ECM remodeling.…

figshare + Loughborough Research Repository2026 · Astronomical catalogue

…Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics.… …Single-cell analysis showed that these genes were predominantly expressed in fibroblasts and associated with fibroblast-state changes and ECM remodeling.…

figshare + Loughborough Research Repository2026 · Astronomical catalogue

…Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics.… …Single-cell analysis showed that these genes were predominantly expressed in fibroblasts and associated with fibroblast-state changes and ECM remodeling.…

figshare + Loughborough Research Repository2026 · Astronomical catalogue

…Single-cell transcriptomic analysis was conducted to assess fibroblast states and gene dynamics.… …Single-cell analysis showed that these genes were predominantly expressed in fibroblasts and associated with fibroblast-state changes and ECM remodeling.…

NCBI GEO2026 · RNA sequencing · 39 samples

…Mammals exhibit limited heart regeneration ability, which can lead to heart failure after myocardial infarction.… …We collected major cardiac cell types from zebrafish and performed high-precision single-cell transcriptome analyses during development and post-injury regeneration.…

NCBI GEO2026 · RNA sequencing · 2 samples

…To accurately illustrate the Changes in the Liver during heart allograft rejection, we established the murine heterotopic heart transplantation model and harvested liver of recipients… …for single cell transcriptome sequencing.…

NCBI GEO2026 · RNA sequencing · 6 samples

…This transformation requires precise spatial and temporal coordination among diverse cardiac cell types; central to this process is cardiomyocyte maturation, yet the regulatory mechanisms… …Here, we present a temporal and spatial atlas of postnatal hearts by integrating single-nucleus transcriptomics with image-based spatial transcriptomics, which uncovers the dynamic…

NCBI GEO2026 · RNA sequencing · 9 samples

…We profiled over 34,000 cells from resected zebrafish hearts spanning 10 developmental stages from 25 hours to 60 days post-fertilization.… …This zebrafish heart atlas enhances our understanding of vertebrate heart development and represents a valuable resource for future studies.…

NCBI GEO2026 · RNA sequencing · 90 samples

…Results: We generate an integrated multiomic atlas of human cardiac cells, combining newly generated and publicly available single-nucleus RNA sequencing datasets from 299 donors and… …single nucleus ATAC-seq datasets from 106 donors.…

NCBI GEO2026 · RNA sequencing · 8 samples

…This transformation requires precise spatial and temporal coordination among diverse cardiac cell types; central to this process is cardiomyocyte maturation, yet the regulatory mechanisms… …Here, we present a temporal and spatial atlas of postnatal hearts by integrating single-nucleus transcriptomics with image-based spatial transcriptomics, which uncovers the dynamic…

NCBI GEO2026 · RNA sequencing · 3 samples

…This transformation requires precise spatial and temporal coordination among diverse cardiac cell types; central to this process is cardiomyocyte maturation, yet the regulatory mechanisms… …Here, we present a temporal and spatial atlas of postnatal hearts by integrating single-nucleus transcriptomics with image-based spatial transcriptomics, which uncovers the dynamic…

NCBI GEO2026 · RNA sequencing · 2 samples

…To determine the activation of PD1+ T cells in MI, we sorted and sequenced PD1+ T cells accompanied with PD1- T cells in the mice heart after MI.… …In order to deeply investigate the function of PD1+ T cells in heart during MI, we performed single-cell RNA sequencing (scRNA-seq) to detect the change T cells from anti-IgG and anti-PD1…

NCBI GEO2026 · RNA sequencing · 3 samples

…Understanding which factors contribute for zebrafish heart regeneration is crucial for developing regeneration-inducing strategies as mammalian hearts are limited in regenerative capacity… …Exploring further our recently published optimized approach for increasing the single cell RNA sequencing (scRNA-seq) resolution specifically CMs, we have systematically evaluated transcription…

NCBI GEO2026 · RNA sequencing · 40 samples

…Here, we established in vivo single-cell RNA metabolic labeling in the adult heart to systematically identify the cells that first respond to injury, as well as the processes that are… …In conjunction with detailed dissection of single-cell transcriptomics atlases, this finding led us to postulate that macrophage-specific inhibition of Toll-like receptor signaling…

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

…<br><br>This PhD thesis aimed to characterise dysregulated gene expression in distinct cardiac cell types during pathological CH using single-cell RNA-sequencing.… …<br><br>After devising a bioinformatic technique to systematically assess conservation in mouse-human cardiac gene expression, dysregulated expression was characterised at the single-cell…

NCBI GEO2026 · RNA sequencing · 4 samples

…Here, we established in vivo single-cell RNA metabolic labeling in the adult heart to systematically identify the cells that first respond to injury, as well as the processes that are… …In conjunction with detailed dissection of single-cell transcriptomics atlases, this finding led us to postulate that macrophage-specific inhibition of Toll-like receptor signaling…

NCBI GEO2026 · RNA sequencing · 15 samples

…Here, we established in vivo single-cell RNA metabolic labeling in the adult heart to systematically identify the cells that first respond to injury, as well as the processes that are… …In conjunction with detailed dissection of single-cell transcriptomics atlases, this finding led us to postulate that macrophage-specific inhibition of Toll-like receptor signaling…

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

…</b> Complete DESeq2 differential expression results for all genes analyzed in estrogen-treated and control cardiac progenitor cells.</p><p dir="ltr"><b>Supplementary Table S5.…

figshare + Loughborough Research Repository2026 · Single-cell RNA sequencing

…Background and Aims<p>Ferroptosis-related pathways have been implicated in cardiovascular remodeling and cancer, but their relevance to hypertensive heart disease (HHD) remains uncertain… …Full-rank cell-level Wilcoxon results were retained, with all single-cell tests treated as descriptive.…

NCBI GEO2026 · RNA sequencing · 2 samples

…While pluripotent stem cell-derived heart organoids model cardiomyocyte differentiation, they do not recapitulate early morphogenetic events.… …Single-cell transcriptomics and trajectory analyses, together with pulse-labeling, support a model in which progressive incorporation of cardiac cells from proliferative splanchnic…

NCBI GEO2026 · RNA sequencing · 294 samples

…This study aimed to clarify the gene expression of each of cardiac neural crest cells during mouse heart development by using Fluidigm C1 system.… …Embryonic hearts from Wnt1-Cre; R26-EYFP mice, which labeled neural crest cells, at E11.5, E12.5, E14.5 and E17.5 were used for single-cell (sc) RNA-seq.…

NCBI GEO2026 · RNA sequencing · 6 samples

…Single cell or single nuclei RNA-sequencing (snRNAseq) enables high-resolution profiling of cellular states, but sample preparation is often costly and complicated by debris formation… …and cell clumping.…

NCBI GEO2026 · RNA sequencing · 12 samples

…The Mexican cavefish provides a unique comparative model to study heart regeneration and scarring within a single species, with Surface fish capable of heart regeneration and their… …Using single-cell transcriptomics and immune perturbations, we find significant differences in the immune response between the two populations.…