Text · study · 2026
Biomarkers for Predicting Therapeutic Response to Preoperative Chemoradiotherapy in Rectal Cancer
Listed in NCBI GEO
This study analyzed 102 rectal cancer patients treated with PCRT and surgery to identify molecular subtypes predicting treatment response.
Description
Using transcriptomic data and pathway-based clustering, an immunogenic cluster was identified, showing high immune activity and a 90.3% favorable response rate. The findings were validated in external datasets, and a 16-gene predictive model demonstrated high accuracy.
These results suggest that immune-related gene expression can guide personalized treatment in rectal cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303720 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303720 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1297161 ncbi.nlm.nih.gov/bioproject/PRJNA1297161 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303720 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.0.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |