10,120 datasets

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

This research aimed to improve the nutritional quality of lamb by exploring and advancing current knowledge surrounding the benefits of pasture feeding for ruminants, focusing on increasing levels of omega-3 (n-3 PUFA) in lamb. The impact of diet on n-3 PUFA composition of lamb meat was evaluated using a systematic review and meta-analysis. Results reinforced the benefits of pasture feeding on n-3

ZivaHub2026 · dataset

ABSTRACT Background Participation in breast cancer screening among culturally diverse women in Australia remains below national targets. Healthcare providers, particularly general practitioners (GPs), play a pivotal role in bridging communication and knowledge gaps and in advocacy, especially for under‐screened South Asian (Pakistani and Indian) women. Objective To explore communication and health

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, heat killed bacterial immunisation and bacterial infection.<br><br>This study hypothesised that follow

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset · unknown

This paper questions the legality of long-term encampment on the grounds that it denies refugees' basic human rights in an arbitrary and discriminatory way, and is therefore inconsistent with international human rights law. Although there were some clear conditions where encampment makes sense, such conditions rarely justify rights restrictions after extended periods of time from a moral or legal

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 8 samples

Interleukin-6 (IL-6) is a pleiotropic cytokine that drives macrophage functions ranging from tissue homeostasis to inflammation, yet how STAT3 specifies these divergent outcomes remains unclear. By integrating transcriptomic and epigenomic profiling with selective STAT3 degradation, we show that STAT3 controls IL-6-induced epigenomic remodeling and restrains a latent STAT1-associated interferon pr

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 6 samples

People living with HIV (PLWH) on antiretroviral therapy (ART) accumulate primarily defective proviral sequences in genomes of often clonally expanded CD4+ HIV-1 target cells. The majority of viral-derived DNA is transcriptionally active and preferentially found at distinct genomic loci suggesting a selective process driven by integration site-specific crosstalk between viral and host sequences. Fo

NCBI GEO2026 · Excel spreadsheet · 14 samples

We identified 5 patients from two families with a defect in antibody production without a known inborn error of immunity.

NCBI GEO2026 · Excel spreadsheet · 35 samples

People living with HIV (PLWH) on antiretroviral therapy (ART) accumulate proviral sequences in genomes of often clonally expanded CD4+ HIV-1 target cells. Viral-derived DNA is preferentially found at distinct genomic loci suggesting a selective process driven by integration site-specific crosstalk between viral and host sequences. Focusing on one of the most prominent selected integration loci, th

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 10 samples

We identified 5 patients from two families with a defect in antibody production without a known inborn error of immunity.

NCBI GEO2026 · RNA sequencing · 9 samples

This work explores tissue-specific biomimetic functional materials and investigates the regulatory mechanisms of materials on cells, offering a highly promising solution for the manufacturing of centimeter-sized injectable liver tissue.

NCBI GEO2026 · RNA sequencing · 18 samples

DNA methylation regulates transcription, yet the demethylation of canonical elements like promoter CpG islands exhibits inconsistent correlations with gene activation. We hypothesized that causal regulatory elements are defined by biophysical hypersensitivity. Profiling 24 whole-genome bisulfite sequencing samples across diverse human and murine models, we identified Methylation Mesa, narrow (~45-

NCBI GEO2026 · RNA sequencing · 6 samples

Spermatogonial stem cells (SSCs) are required for initiating and maintaining normal spermatogenesis, and notably, they have significant applications in both reproductive and regenerative medicine owing to their great plasticity with de-differentiation and trans-differentiation potentials. Nevertheless, molecular mechanisms regulating human SSC fate determinations and male fertility remain elusive.

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 4 samples

Interleukin-6 (IL-6) is a pleiotropic cytokine that drives macrophage functions ranging from tissue homeostasis to inflammation, yet how STAT3 specifies these divergent outcomes remains unclear. By integrating transcriptomic and epigenomic profiling with selective STAT3 degradation, we show that STAT3 controls IL-6-induced epigenomic remodeling and restrains a latent STAT1-associated interferon pr

NCBI GEO2026 · RNA sequencing · 204 samples

RNA sequencing was performed on human stem cell-derived neuronal cultures across developmental and experimental conditions, including differentiated neurons exposed for 24 h to the mitochondrial complex I inhibitor rotenone at 0.06, 0.25, 0.5 or 1 µM. The transcriptomic data were generated to support characterisation of human dopaminergic neuronal metabolism and integration with quantitative exome

NCBI GEO2026 · RNA sequencing · 2 samples

As direct experimentation on the healthy human brain is ethically limited, developing brain models is essential. Currently, research groups employ complex in vitro brain organoid models, three-dimensional (3D) structures that mimic aspects of the human brain architecture. These organoids self-organize into small clusters that resemble key features of the developing brain, including functional neur

NCBI GEO2026 · RNA sequencing · 12 samples

Introduction: Macrophages are essential components of the innate immunity, serving as a frontline defense against pathogens and contributing to tissue homeostasis. The generation of human induced pluripotent stem cell (iPSC)-derived macrophages (iMacs) provides a valuable platform for studying human innate immunity and macrophage biology. This study presents a robust, reproducible, and efficient p

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 18 samples

Precise and rapid control over cellular protein levels is essential to dissect complex biological systems. Chemical genetic approaches such as dTAG, in which a target is fused to a degron tag (FKBP12F36V) and degraded upon small molecule-mediated recruitment of E3 ligases, have enabled rapid and tunable control over protein abundance. However, no analogous tool exists to precisely increase protein

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 7 samples

People living with HIV (PLWH) on antiretroviral therapy (ART) accumulate primarily defective proviral sequences in genomes of often clonally expanded CD4+ HIV-1 target cells. The majority of viral-derived DNA is transcriptionally active and preferentially found at distinct genomic loci suggesting a selective process driven by integration site-specific crosstalk between viral and host sequences. Fo

NCBI GEO2026 · Table · CSV · 2 samples

Immunomodulatory drugs (IMiDs) are a cornerstone of multiple myeloma treatment and newer cereblon E3 ligase modulating drugs (CELMoDs) are in clinical trials. However, a major barrier to improving patient outcomes is the inevitable development of resistance to these agents. To explore the mechanisms underlying IMiD/CELMoD resistance, and identify novel targets for treatment, human cell line models

NCBI GEO2026 · RNA sequencing · 14 samples

Apolipoprotein E4 (APOE4), the strongest genetic risk factor for late-onset Alzheimer's disease, promotes neuronal dysfunction through incompletely understood mechanisms. Here, we integrated transcriptomic, translatomic, and proteomic profiling of isogenic human iPSC-derived APOE3 and APOE4 neurons and found that APOE4 fundamentally impairs neuronal proteome renewal. Although transcriptional chang

NCBI GEO2026 · Methylation profiling by genome tiling array · 40 samples

This project aims to identify CNVs of intracranial and extracranial germ cell tumors in the Thai population. Formalin-fixed paraffin-embedded tissues (FFPET) from intracranial (IGCTs) and extracranial germ cell tumors (EGCTs) were extracted and analyzed using SNP microarray, and somatic CNVs were also investigated. Pathway enrichment analysis and associations between significant CNVs, clinical par

NCBI GEO2026 · RNA sequencing · 60 samples

This SuperSeries comprises transcriptomic and epigenomic datasets generated in human macrophages to investigate IL-6-STAT3 signaling. The datasets include RNA-seq under STAT3 degradation and JAK inhibition, IL-6 time-course RNA-seq, hMDM RNA-seq, ATAC-seq, and CUT&Tag profiling of H3K27ac, STAT3, and STAT1. Together, these data characterize IL-6-induced chromatin and transcriptional changes and th

NCBI GEO2026 · Sequencing data · 8 samples

Although mutations in genes encoding histones display a similar prevalence to that of some other somatic mutations in cancer, the underlying mechanisms by which histone mutations drive tumorigenesis have not been fully explored. Herein, we curated missense mutations occurring in core histone genes in breast cancers using data from MSK-IMPACT and cBioPortal to identify high frequency breast cancer-

NCBI GEO2026 · RNA sequencing · 9 samples

Proline/arginine-rich end leucine-rich repeat protein (PRELP) is an extracellular matrix-associated protein involved in tissue remodeling and immune regulation. This study investigates PRELP-associated transcriptional changes in human melanoma using bulk RNA sequencing of PRELP-low, PRELP-high, and PRELP + Toll-like receptor 2 (TLR2) co-transfected BUF1088 cells. PRELP-high cells were generated by

NCBI GEO2026 · RNA sequencing · 25 samples

Efforts to analyze breast cancer transcriptomes at scale have been limited by cross-study technical variability. To address this, we adapted single cell RNA sequencing analytical strategies to harmonize 7,612 bulk breast cancer transcriptomes from 22 datasets, generating a high resolution atlas that resolves both known and previously unrecognized malignant transcriptional states. This framework id