Omics · study · 2026
The genetic landscape of a human cell reveals conserved topology and principles of genetic networks
Listed in NCBI GEO
We generated a genome-scale, genetic interaction network from the analysis of more than 5 million double mutants in the haploid human cell line, HAP1.
Description
The network comprises ~90,000 negative and positive genetic interactions, including thousands of extreme synthetic lethal and genetic suppression interactions. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments.
Systematic comparative analyses showed that the general principles and topology of genetic networks are conserved from yeast to humans. A genetic interaction network mapped in a single genetic background complements the DepMap cancer cell co-essentiality network, recapitulating many of the same functional connections and also capturing unique functional information to reveal roles of previously uncharacterized genes and molecular determinants of specific cancer cell line genetic dependencies.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE296nnn/GSE296341 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296341 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1258952 ncbi.nlm.nih.gov/bioproject/PRJNA1258952 ↗
project · from NCBI GEO
- PubMed 42049019 pubmed.ncbi.nlm.nih.gov/42049019 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · Genome structure and regulation 77%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE296341 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:310508 | enrichment · NCBI GEO | taxonomy-embedding@1.0.0 | title+keywords+description (77%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |