Omics · study · 2026
Wdr82-COMPASS coordinates Foxp3 and TCR signaling to sustain Treg control of microbiota-driven intestinal inflammation [CutRun PolII,Ser2/5P]
Listed in NCBI GEO
Immune homeostasis relies on a delicate equilibrium between effector T (Te) cells and regulatory T (Treg) cells.
Description
Understanding the differential regulation of these cells would provide valuable insights into this crucial process and associated diseases. Here, we conduct a comprehensive search and identify the H3K4me3 pathway as a key regulator.
Using Wdr82, a component of the Set1/COMPASS histone H3K4 methyltransferase complex, as a model, we discover that this pathway is required to facilitate both Te and Treg activation and function. Counterintuitively, its attenuation via Wdr82 conditional deletion in all T cells leads to Te activation, causing lethal spontaneous colitis. This dysregulation is nearly completely prevented by microbiome depletion or wild-type Treg transfer.
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Mechanistically, the H3K4me3 pathway is preferentially required for Treg induction and upregulation of Treg functional genes such as Il10 and Rorc. Thus, the generic H3K4me3 pathway plays a biased role in Treg-dependent immune homeostasis, particularly in the gut.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344913 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344913 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1517874 ncbi.nlm.nih.gov/bioproject/PRJNA1517874 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE344913 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |