7,568 datasets

HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · RNA sequencing

<p dir="ltr">Pseudobulk genome-wide transcription from whole adult mouse lung. Three groups: healthy (no treatment), 4wkHDM (after 4 weeks of intranasal house dust mite exposure), and 6wkHDM (after 6 weeks of intranasal house dust mite exposure).</p>

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Elongation of the anteroposterior (AP) axis in vertebrates relies on a pool of stem cell-like Neuromesodermal competent cells (NMCs) that supply the neural tube and paraxial mesoderm with progenitors during embryogenesis. A finely tuned balance between NMC self-renewal and commitment to neural or mesodermal fates governs NMC homeostasis. This balance is orchestrated by converging Wnt, FGF and reti

ZivaHub + Deakin Research Online + DMU Figshare + HKU DataHub + Swinburne Figshare + DaYta Ya Rona + SUNScholarData + figshare + Loughborough Research Repository + GRANTS Data + UP Research Data Repository2026 · Astronomical catalogue

<p dir="ltr">We use fiber photometry in awake freely-moving mice to investigate how the VTA represents auditory stimuli. We compared VTA responses to those in the inferior colliculus (IC) recorded with the same technique. Neural activity in the VTA exhibited robust responses to a wide variety of auditory stimuli, including broadband noise, pure tones, and music stimuli. We identified a subset of s

ZivaHub + Deakin Research Online + DMU Figshare + UCL Research Data Repository2026 · dataset · unknown

The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, heat killed bacterial immunisation and bacterial infection.<br><br>This study hypothesised that follow

NCBI GEO2026 · RNA sequencing · 14 samples

Impaired alveolar regeneration underlies numerous chronic lung diseases, yet the metabolic determinants governing this process remain poorly understood. Effective alveolar repair depends on the differentiation of type 2 alveolar epithelial cells (AT2), the resident lung stem/progenitor cells, into type 1 alveolar epithelial cells (AT1) to restore gas exchange surfaces. Here, we reveal that glutami

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 12 samples

Memory follicular helper T cells (TFH) are essential for rapidly re-eliciting sufficient effector TFH cells in facilitating B cells to produce high-affinity neutralizing antibody against re-infection. However, the mechanism underlying memory TFH cell differentiation is largely unknown. Here, we show that a subset of antigen-specific CD4 effector cells highly expressing transcription factor Hhex (H

NCBI GEO2026 · Raster · GeoTIFF · 3 samples

The dorsal horn is remarkably diverse, yet how this cellular complexity enables discrimination of sensory modalities remains a fundamental question. Neurons expressing gastrin-releasing peptide receptor (Grpr+) have long been considered dedicated to itch, yet broad activation also evokes pain-related behavior. Whether Grpr+ neurons are required for pain, and how itch- and pain-related functions ar

NCBI GEO2026 · RNA sequencing · 50 samples

This SuperSeries is composed of the SubSeries listed below.

NCBI GEO2026 · RNA sequencing · 46 samples

Shortly after mitosis, a wave of hyper-transcription reactivates the genome, especially in mouse embryonic stem (ES) cells, where rapid reactivation is essential for self-renewal and pluripotency. While recent work has illuminated how specific groups of genes are reactivated, whether dedicated mechanisms enable the global, efficient and accurate post-mitotic reactivation of the genome remains unkn

NCBI GEO2026 · study · 14 samples

Prenatal cannabis use is increasing, yet the effects of inhaled cannabis smoke on placental molecular function remain poorly defined. The goal of this study was to characterize placental transcriptomic alterations following prenatal cannabis smoke exposure using a physiologically relevant inhalation model. Timed-pregnant CD1 mice were exposed to cannabis cigarette smoke or room air from embryonic

NCBI GEO2026 · RNA sequencing · 2 samples

Purkinje cells are specialized cardiomyocytes coordinating rapid electrical propagation for synchronized heart contraction. Although these cells were described over a century ago, their molecular and cellular features under physiological conditions and after myocardial infarction are not fully understood. Here we show that single nucleus transcriptome sequencing identifies three types of Purkinje

NCBI GEO2026 · RNA sequencing · 6 samples

Pathological cardiac remodeling under chronic stress load is a key process in the progression of heart failure (HF), but its underlying molecular mechanisms are not yet fully understood, which limits the development of therapeutic approaches. In this study, we identified serine/threonine kinase 39 (STK39) as a key mediator, showing that it is significantly upregulated in human hypertrophic hearts

NCBI GEO2026 · RNA sequencing · 2 samples

Spermatogonial stem cells (SSCs) are required for initiating and maintaining normal spermatogenesis, and notably, they have significant applications in both reproductive and regenerative medicine owing to their great plasticity with de-differentiation and trans-differentiation potentials. Nevertheless, molecular mechanisms regulating human SSC fate determinations and male fertility remain elusive.

NCBI GEO2026 · RNA sequencing · 14 samples

Circadian rhythms coordinate daily fluctuations in physiology and behavior, yet their organization within primary sensory pathways remains poorly defined. Although somatosensory responsiveness varies across the day-night cycle, it is unclear whether peripheral sensory circuits possess molecular mechanisms for temporal regulation. Here, we demonstrate that the spinal-peripheral sensory axis harbors

NCBI GEO2026 · RNA sequencing · 10 samples

The developing mammalian embryo is guided by the continuously changing signals that it receives from maternal tissues and its microenvironment. The dynamic cell-cell and cell-environment interactions that together shape the embryo largely remained unexplorable until the advance of stem cell-based embryo models. These revealed the self-organizing properties of cells in response to endogenous and ex

NCBI GEO2026 · Genome binding/occupancy profiling by high throughput sequencing · 4 samples

Memory follicular helper T cells (TFH) are essential for rapidly re-eliciting sufficient effector TFH cells in facilitating B cells to produce high-affinity neutralizing antibody against re-infection. However, the mechanism underlying memory TFH cell differentiation is largely unknown. Here, we show that a subset of antigen-specific CD4 effector cells highly expressing transcription factor Hhex (H

NCBI GEO2026 · RNA sequencing · 37 samples

Early-life exposure to high-fat diet (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies reported the impact of maternal HF on this structure. We assessed the effects of maternal HF during lactation on physiological, metabolic and cognitive parameters in young adult offspring mice. T

NCBI GEO2026 · RNA sequencing · 32 samples

Abstract Background Epileptogenesis transforms a healthy brain into an epileptic network, yet the temporal and cell-type-specific molecular events driving this transition remain poorly defined. Neuron-glia interactions are essential in this process, but no study has systematically charted their transcriptional dynamics from the acute insult to chronic epilepsy. Methods Using the intracortical kain

NCBI GEO2026 · RNA sequencing · 8 samples

Adipose tissue expansion in obesity frequently outpaces vascularization, triggering hypoxia, fibrosis, and metabolic dysfunction. The molecular mechanisms coordinating adaptive angiogenesis during this expansion remain poorly understood. Here, we demonstrate that macrophage-specific deletion of Transcription Factor EB (Tfeb) in high-fat diet-fed mice exacerbates epididymal white adipose tissue (eW

NCBI GEO2026 · RNA sequencing · 21 samples

T-cell acute lymphoblastic leukemia (T-ALL) spreads aggressively to the central nervous system (CNS), particularly the leptomeninges. Children with T-ALL are treated with high-dose, CNS-directed chemotherapy, which can cause lasting neurotoxicity and is not always effective. Little is known about how T-ALL enters and persists within the CNS. However, normal T cell migration into the CNS has been e

HKU DataHub + figshare + Loughborough Research Repository2026 · Astronomical catalogue

<p>Glyphosate is the most heavily applied herbicide worldwide and human exposure is now near-ubiquitous, yet its renal toxicity at near-threshold doses remains incompletely characterized. We tested whether subacute oral glyphosate produces integrated, dose-dependent renal injury in male mice (<i>Mus musculus</i>). Adult male mice (n = 10/group) received vehicle or technical-grade glyphosate at 10,

NCBI GEO2026 · Excel spreadsheet · 6 samples

Background/Objectives: Inflammatory bowel disease (IBD) is a chronic, immune-mediated inflammatory disorders of the gastrointestinal tract. Reynoutrin is a flavonoid from Psidium cattleianum, with antioxidant and radical-scavenging activity. However, whether reynoutrin could mediate its therapeutic effects on IBD has not been addressed. Methods: We employed dextran sulfate sodium (DSS)-induced col

NCBI GEO2026 · RNA sequencing · 3 samples

Memory follicular helper T cells (TFH) are essential for rapidly re-eliciting sufficient effector TFH cells in facilitating B cells to produce high-affinity neutralizing antibody against re-infection. However, the mechanism underlying memory TFH cell differentiation is largely unknown. Here, we show that a subset of antigen-specific CD4 effector cells highly expressing transcription factor Hhex (H

NCBI GEO2026 · RNA sequencing · 20 samples

To investigate cochlear transcriptomic responses to chronic hypobaric hypoxia, male C57BL/6J mice were assigned to an ambient-pressure control group or exposed to simulated high-altitude hypobaric hypoxia for 2, 4, or 6 weeks. A staggered-entry design was used so that all groups underwent terminal cochlear tissue collection on the same day. Bulk RNA sequencing was performed on 20 independent cochl

NCBI GEO2026 · Excel spreadsheet · 12 samples

Unresolved endoplasmic reticulum (ER) stress is deleterious in cardiovascular diseases, including myocardial infarction (MI). Under adaptive ER stress, activation of the unfolded protein response (UPR) is accompanied by increased mitochondrial calcium at mitochondrial-endoplasmic reticulum contact sites (MERCs), which enhances metabolism and restores homeostasis. The identity of this calcium sourc