Omics · study · 2026
Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection
Listed in NCBI GEO
Urinary tract infections (UTI) are frequent and highly inflammatory.
Description
Using a pyelonephritis mouse model, we investigated the impact of pyelonephritis on the development of atherosclerosis. Bulk RNA sequencing analysis of kidneys and aortas harvested four weeks post-infection was performed to identify key molecular markers and delineate differentially regulated inflammatory pathways in both organs.
Our results show an upregulation of inflammatory mediators in kidney and aorta, providing a possible mechanistic link between pyelonephritis and atherosclerosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313813 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313813 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1381629 ncbi.nlm.nih.gov/bioproject/PRJNA1381629 ↗
project · from NCBI GEO
- PubMed 41930659 pubmed.ncbi.nlm.nih.gov/41930659 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313813 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |