Omics · study · 2026
S100A4 inhibition alters pre-metastatic niche formation in 4T1 lung metastasis model
Listed in NCBI GEO
Cancer metastasis poses a major clinical challenge and is responsible for ~90% of cancer-associated deaths.
Description
However, progress in treating metastatic disease is limited. S100A4/FSP1 has long been associated with cancer metastasis, including breast cancer.
In this study, we report preclinical efficacy data of a novel S100A4 blocking antibody that suppresses breast cancer metastasis. 4T1 and MMTV-PyMT breast cancer metastasis to the lung is greatly attenuated by S100A4 blocking antibody treatment. Immunohistochemistry analysis shows that neutrophil infiltration is significantly reduced in the anti-S100A4 treated mice. Single-cell RNA sequence analysis of the premetastatic niche treated with either isotype control or anti-S100A4 antibody from the 4T1 model show that NK and T cell activation in the lung.
Read the rest (1 more)
In this study, we report that S100A4 promotes premetastatic niche formation by promoting neutrophil infiltration and suppressing the function of cytotoxic NK and T cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284668 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284668 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1200016 ncbi.nlm.nih.gov/bioproject/PRJNA1200016 ↗
project · from NCBI GEO
- PubMed 41962622 pubmed.ncbi.nlm.nih.gov/41962622 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE284668 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |