ZFP90 deficiency exacerbates high fat diet-induced hepatic transcriptomic remodeling.

Pathway enrichment analysis revealed that ZFP90 deficiency upregulated programs involved in immunity, inflammatory responses, and lipid metabolism-specific cytokine-cytokine receptor interactions, NF-κB, and chemokine signaling. To explore the mechanisms underlying ZFP90 deficiency-induced hepatic steatosis, we assessed hepatic gene expression based on RNA-seq data.

ZFP90 deficiency increased mRNA levels of genes related to fatty acid uptake, inflammation, and fibrosis, indicating that ZFP90 loss accelerates MASLD progression through integrated inflammatory and metabolic pathways.