Omics · study · 2026
Immune and Repair Mechanisms Underlying Congenital Chagas
Listed in NCBI GEO
In this study, we conducted integrative high-throughput analyses of peripheral blood and placental tissue from naturally infected patients in Bolivia, the country with the highest prevalence of Chagas disease and, consequently, the population with the greatest potential for congenital transmission worldwide.
Description
We compared T. cruzi-infected and uninfected patients to characterize parasite-associated alterations. Infected mothers were further classified as transmitters or non-transmitters based on the infant’s infection status, determined by serological and molecular tests.
Transmitter and non-transmitter mothers were compared to understand the molecular mechanism associated with congenital transmission risk.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE311nnn/GSE311812 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311812 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1370941 ncbi.nlm.nih.gov/bioproject/PRJNA1370941 ↗
project · from NCBI GEO
- PubMed 41648170 pubmed.ncbi.nlm.nih.gov/41648170 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE311812 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |