Omics · study · 2026
SRPK2 overexpression remodels the transcriptome landscape of triple-negative breast cancer cells
Listed in NCBI GEO
SRPK2 (SRSF protein kinase 2) is a serine/arginine-rich protein-specific kinase that phosphorylates SR splicing factors and regulates pre-mRNA alternative splicing.
Description
SRPK2 is highly expressed in breast cancer and associated with poor prognosis. To characterize how SRPK2 remodels gene expression in triple-negative breast cancer, we performed strand-specific RNA-seq of MDA-MB-231 cells transiently transfected with a SRPK2-FLAG expression plasmid (OE) or the corresponding empty vector (NC).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338307 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338307 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1493197 ncbi.nlm.nih.gov/bioproject/PRJNA1493197 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338307 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |