Omics · study · 2026
Identification and enrichment of human retinal organoid-derived red/green cone-competent precursors with enhanced axon dynamics
Listed in NCBI GEO
Cell replacement therapies aimed at restoring central vision require a source of red/green (long/medium wavelength, or L/M) cone photoreceptors with integrative properties.
Description
Toward this end, we developed a means to identify early L/M cone precursors from human pluripotent stem cell-derived retinal organoids (ROs) by linking tdTomato to the endogenous THRB2 promoter. Subsequent bulk RNA sequencing of fluorescence-activated cell sorted ROs showed that very early L/M cones were specifically enriched in genes associated with neural development, axon extension guidance, and cell migration.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310055 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310055 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1365073 ncbi.nlm.nih.gov/bioproject/PRJNA1365073 ↗
project · from NCBI GEO
- PubMed 42401922 pubmed.ncbi.nlm.nih.gov/42401922 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310055 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |