Omics · study · 2026
Epigenetic alterations of the imprinted SLC22A18 gene contributed to congenital "Allergy-Short-stature-fatty liver" syndrome by via β-catenin-Ascl2 axis
Listed in NCBI GEO
Epigenetic syndrome is a multisystem, eternal, and devastating disease associated with imprinted gene variants.
Description
Our previous study showed a strong correlation between the SLC22A18 and the "Allergy-Short stature-fatty liver" (ASFL) syndrome in children. However, the mechanisms by which SLC22A18 influences ASFL syndrome remain unknown.SLC22A18 deficiency also induced higher lipid accumulation in liver in the mouse model.
Whether SLC22A18 deletion promotes hepatic steatosis deserves further investigation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE322nnn/GSE322487 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE322487 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1429432 ncbi.nlm.nih.gov/bioproject/PRJNA1429432 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE322487 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |