GM25056 deficiency alleviates senescence in articular chondrocytes

Alternative splicing (AS), as a post-transcriptional regulatory mechanism, plays a central role in gene expression across eukaryotic cells including chondrocytes. The spliceosome, regulated by catalytic core components including single or multiple small nuclear RNAs (snRNAs), governs AS.

Within the nucleus, snRNAs specifically bind to precursor messenger RNA (pre-mRNA) sequences, directly participate in splice site recognition and spliceosome assembly, and guide cleavage/re-ligation to generate mature mRNA for cytoplasmic export. However, the precise role of snRNAs in chondrocyte senescence and osteoarthritis pathogenesis remains incompletely understood. This study investigates the impact of snRNA GM25056 on chondrocyte senescence and its underlying mechanisms.