Omics · study · 2026
Epigenomic changes in chromatin accessibility following 1,25-dihydroxyvitamin D3 treatment in human endometrial stromal cells
Listed in NCBI GEO
Chromatin accessibility is a key determinant of gene regulation and cellular responsiveness to hormonal signaling.
Description
Although vitamin D has been implicated in diverse biological processes, its effects on chromatin accessibility in human endometrial stromal cells remain incompletely characterized. In this study, the impact of 1,25-dihydroxyvitamin D₃ on chromatin accessibility was examined using ATAC-seq.
Overall, these findings indicate that 1,25-dihydroxyvitamin D₃ is associated with changes in chromatin accessibility in human endometrial stromal cells and suggest a potential epigenomic basis for vitamin D–mediated cellular responses.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326063 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326063 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1443262 ncbi.nlm.nih.gov/bioproject/PRJNA1443262 ↗
project · from NCBI GEO
- PubMed 42146510 pubmed.ncbi.nlm.nih.gov/42146510 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Genetics 68%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326063 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |