Excel · study · 2026
Ion Torrent RNA-sequencing of microdissected chemorefractory and chemosensitive high-grade serous ovarian cancer samples
Listed in NCBI GEO
Description
To identify miRNAs that are associated with intrinsic chemoresistance, we performed next-generation Ion Torrent miRNA-sequencing analysis on RNA isolated from microdissected chemo-refractory samples (i.e., tumors not responsive to initial chemotherapy) and microdissected chemo-sensitive samples (i.e., tumors with relapsed HGSC 6 months after the last cycle of chemotherapy) of treatment-naïve advanced high-grade serous ovarian cancer (HGSC).
We identified an miRNA signature with a set of miRNAs and their variants that showed significant differential copy numbers in chemo-refractory samples compared to chemo-sensitive samples.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301196 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301196 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1284253 ncbi.nlm.nih.gov/bioproject/PRJNA1284253 ↗
project · from NCBI GEO
- PubMed 41827805 pubmed.ncbi.nlm.nih.gov/41827805 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 69% · Cancer 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301196 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |