Omics · study · 2026
RICTOR prevents decidualization disorder in women with advanced maternal age via regulating FoxO1 nuclear export
Listed in NCBI GEO
Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization. mTORC2 is an evolutionarily conserved protein kinase.
Description
As a core component of mTORC2, RICTOR has been implicated in nutrient sensing and is closely linked to implantation disorders, though its role in regulating age-related decidualization disorder is unreported. In this study, we observed severe decidualization defects in AMA foster mice.
The expression of RICTOR was significantly reduced in the decidual tissues of AMA females. Uterine-specific genetic deletion of Rictor in mice resulted in pregnancy loss and impaired decidualization. Notably, Rictor knockdown led to attenuated Akt3–FoxO1 signaling and impaired nuclear export of FoxO1.
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Molecular and histological analyses demonstrated that the specific RICTOR activator MHY-1485 could effectively rescue decidualization defects both in vivo and in vitro. These findings indicate that RICTOR plays an essential role in the aging decidual microenvironment and may serve as a potential biomarker for uterine stromal cell decidualization. Furthermore, therapeutic activation of RICTOR represents a promising strategy to counteract senescent decidual impairment in AMA women and improve pregnancy outcomes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310105 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310105 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1365133 ncbi.nlm.nih.gov/bioproject/PRJNA1365133 ↗
project · from NCBI GEO
- PubMed 42626765 pubmed.ncbi.nlm.nih.gov/42626765 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310105 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |