Omics · study · 2026
Bacteria-mimicking cancer cells reprogram macrophages via multiple PRR pathways for cancer immunotherapy
Listed in NCBI GEO
Although macrophages are a powerful cell-based platform for cancer immunotherapy, their antitumor functions, such as phagocytosis and inflammatory responses, are limited by the immunosuppressive tumor microenvironment.
Description
Here, we show that decorating cancer cell membranes with bacteria-derived pathogen-associated molecular patterns (PAMPs) initiates phagocytosis and inflammatory responses of macrophages toward cancer cells involving various pattern recognition receptor signaling.
Membrane-attached PAMP nanoparticles maintained their immunostimulatory functions. The phagocytic macrophage fraction increased when coincubated with membrane-decorated cancer cells, along with an increased secretion of inflammatory cytokines. Transcriptome analysis revealed that the response of macrophages to PAMP-decorated cancer cells resembled their response to bacteria.
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In a mouse model, locally injected membrane-decorating PAMP nanoparticles suppressed tumor growth, and the effect was enhanced in combination with the chemotherapeutic drug doxorubicin. Our findings provide insights into the use of macrophages as a cancer immunotherapy modality.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327369 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327369 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1450603 ncbi.nlm.nih.gov/bioproject/PRJNA1450603 ↗
project · from NCBI GEO
- PubMed 42503515 pubmed.ncbi.nlm.nih.gov/42503515 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327369 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |