Supplementary file 1_Patient-reported outcomes in adults with type 3c diabetes: a scoping review across aetiologies and pancreatic resection extent.docx

In a reproducible post hoc random validation sample of 200 of 3,321 early exclusions, exact and binary reviewer agreement were 100% (Cohen’s kappa = 1.00); three records marked unclear by both reviewers were excluded after targeted adjudication, leaving no eligible record in the sample (0/200; Wilson 95% confidence interval 0–1.88%). Twenty-six included reports concerned pancreatic resection or an insulin-treated TPIAT subgroup, 11 cystic-fibrosis-related diabetes, two diabetes secondary to chronic pancreatitis and one fibrocalculous pancreatic diabetes.

Generic health and physical function were often impaired after total pancreatectomy, whereas some comparator studies reported similar PAID, ADDQoL or treatment-satisfaction results to type 1 or other insulin-treated diabetes. No report used SARC-F. Only six reports were available to the authors in full text; the favorable technology signals depended on abstract-based reports and were therefore hypothesis-generating.</p>Conclusions<p>Patient-reported burden in type 3c diabetes is multidimensional and measurement remains fragmented.

Future studies should combine complementary measures and report aetiology, diabetes timing and total versus partial resection explicitly.</p>